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许田博士简介(Tian Xu, Ph.D.)
>> > 1962年出生于浙江省嘉兴市。1978-1982年就读于复旦大学谈家祯教授主持的遗传学专业。毕业后留校任教于生物系和遗传学研究所
。1983年带50美元来到纽约哈蓝姆穷人区艰苦奋斗。1984年获耶鲁大学奖学金读博士。从师于著名发育遗传学家S. Artavanis-Tsakonas教授
研究神经发育分子遗 传学机理。1990年获得博士,以其成绩在全美博士毕业生中获20人之一的美国海伦黑—慧特尼(Helen Hay Whitney) 博
士后奖。于1990-1993年在加州 大学伯克莱分校分子细胞生物系随著名遗传学家GeraldRubin(美国科学院院士)做博士后研究。1993年受聘
于耶鲁大学医学院任遗传学、发育生物学、分子肿瘤学助理教授,并兼职于癌症研治中心和Boyer分子医学中心。1998年任副教授,2001年成
为耶鲁大学终生教授。
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>> > 研究主攻方向是用新的遗传学方法鉴别导致疾病基因(如癌症、神经系统功能减退、缺氧症)。建立动物疾病模型、通过研究果蝇、小鼠
、人细胞中致病基因功能来寻找发育和疾病的遗传分子调控机理。曾为Nocth信号转导途径研究作出重大贡献。他发明了在全世界数千家果蝇
实验室中广泛使用的镶嵌体分析技术,发表文章是在遗传学和发育生物学领域被引用最多的文献之一。他首先发明用镶嵌体技术筛选肿瘤抑
制基因等疾病基因,并首创了肿瘤发生和缺氧反应等的果蝇模型。他找到了lats等肿瘤抑制基因家族,发现这些基因的发育生物学功能是调
控器官及组织大小,并首先提出了肿瘤发生和器官大小调控有关的理论。近期用果蝇模型发现了结节性硬化综合征疾病基因TSC的功能并确定
其参与调控胰岛素信号转导。为治疗结节性硬化和糖尿病提供了新的依据。他在动物疾病模型和器官大小调控理论研究中处于世界领先地位
。1994年以来在哈佛、剑桥等众多大学、企业及国际会议应邀讲学80多次。研究成果在Science、Cell、Nature Genetics、Development等杂
志发表。撰写学术专著2本。镶嵌遗传筛选法的发明人,拥有6项国际专利。1995年获PEW学者奖。1997年在全美竞争中成为著名休斯医学研
究院成员。并获得美国肿瘤学会研究基金、Donaghue医学研究基金、路夕列P·马基托拉斯科研基金、和美国国家卫生总署颁发的研究基金。
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>> > 在耶鲁大学教学函盖遗传分析、发育生物学、疾病模型、模式生物学、分子肿瘤学、人类遗传疾病学、分子细胞学等课程。其创办并主
持的遗传分析课从1998年开创以来一直是耶鲁大学最受欢迎的研究生课。1994年以来在耶鲁大学先后指导13位博士研究生及10位博士后。毕
业学生和博士后中已有4位在美国和中国大学任助理教授和副教授 (如明尼苏达大学)。曾任耶鲁大学Boyer分子医学中心、细胞学系、遗传系
的多个教授招聘委员会成员,耶鲁大学遗传学系系主任招聘联系委员会成员,遗传学系研究生兼主任。现任耶鲁大学遗传学系研究生指导委
员会委员,遗传学系及发育生物部研究生招生委员会主任,耶鲁大学小鼠基因组委员会成员。
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>> > 1996年以来参加多个国际科学、学术及基金会委员会工作,包括美国科学院美中前沿科学交流委员会,HULL肿瘤研究评奖委员会委员
,Leslie-Warner研究基金评委,安娜赫尔博士基金会委员。 曾参加中国国家自然科学基金会、意大利Tele Thon科学基金会、加拿大医学
研究基金会、以色列科学基金会、台湾中研院青年学者奖、英国Wellcome Trust基金会评审。现任吴瑞协会副会长,北美华人生物科学家学
会财务部主任。
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>> > 关心祖国科学、教育、医药发展。每年多次回国进行教学、研究工作,参加基金评审,主持学术会议。1996年起应谈家祯教授邀请在复
旦大学展开工作任客座教授,每年讲授发育遗传学,将耶鲁大学课程移植到中国获得好评。2000年和韩珉教授一起在复旦大学建立发育生物
学基地,从事发育和疾病研究,并获得中国国家自然科学基金会功能基因组重点基金。98年任中科院发育研究所客座研究员, 参加中国科学
院研究生课教学(2000年分子生物学和细胞生物学,最受欢迎的教师)。2000年起任中国科学院海外评审专家和高等教育出版社《当代科学前
沿论坛丛书》专家委员会委员。积极促进中美学术交流, 接受美国科学院院长Bruce Alberts委托组织美中前沿科学学术交流, 97-99任交流
委员会成员, 99-00任
>> > 主席。
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>> > Publications:
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>> > Lin, P.F., Liberman, H.B., Yeh, D.B., Xu, T., Zhao, S.Y., Ruddle, F.H. (1985). Molecular cloning and structural
analysis of murine thymidine kinase genomic and cDNA sequences. Mol. Cell. Biol. 5: 3149-3156.
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>> > Wharton, K.A., Johansen, K.M., Xu, T., Artavanis-Tsakonas, S. (1985). Nucleotide sequence from the neurogenic locus
Notch implies a gene product that shares homology with proteins containing EGF-repeats. Cell 43: 567-581.
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>> > Hartley, D.A., Xu, T., Artavanis-Tsakonas, S. (1987). The embryonic expression of the Notch locus of Drosophila
melanogaster and the implications of point mutations in the extracellular EGF-like domain of the predicted protein. EMBO
6: 3407-3417.
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>> > Xu, T., Rebay, I., Fleming, R.J., Scottgale, T.N. and Artavanis-Tsakonas, S. (1990) The Notch locus and the genetic
circuitry involved in early Drosophila neurogenesis. Genes and Development 4: 464-475.
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>> > Fehon R.G., Kooh, P.J., Rebay, I., Regan, C.L., Xu, T., Muskavitch, M.A.T. and Artavanis-Tsakonas, S. (1990). Molecular
interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila
. Cell 61: 523-534.
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>> > Xu, T. and Artavanis-Tsakonas, S. (1990). deltex, a locus interacting with the neurogenic genes, Notch, Delta, and
mastermind in Drosophila melanogaster. Genetics 126: 665-677.
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>> > Artavanis-Tsakonas, S., Delidakis, C., Fehon, R.G., Hartley, D.A., Herndon, V., Johansen, K.M., Markopoulou, K., Preiss,
A., Rebay, I., Scottgale, T.N. and Xu, T. (1990). Notch and the molecular genetics of neuroblast segregation in
Drosophila. Mol. Reproduction and Development 27: 23-27.
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>> > Xu, T., Caron, L. A., Fehon , R.G. and Artavanis-Tsakonas, S. (1992). The involvement of the neurogenic locus notch in
Drosophila oogenesis. Development, 115: 913-922.
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>> > Xu, T. and Rubin, G.M. (1993). Analysis of genetic mosaics in developing and adult Drosophila tissues. Development,
117: 1223-1237.
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>> > Busseau. I., Diederich, R.J., Xu, T. and Artavanis-Tsakonas, S. (1994). A member of the Notch group of interacting
loci, deltex encodes a cytoplasmic basic protein. Genetics, 136: 585-596.
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>> > Xu, T. and Harrison, S. (1994). Mosaic analysis using FLP recombinase. Methods in Cell Biol., 44: 655-682.
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>> > Xu, T., Wang, W., Zhang, S., Stewart, R.A., Yu, W. (1995). Identifying tumor suppressors in genetic mosaics: the
Drosophila lats gene encodes a putative protein kinase. Development, 121: 1053-1063.
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>> > Rooke, J., Pan, D., Xu, T.* and Rubin, G.M. (1996). KUZ, a conserved metalloprotease/disintegrin protein, plays two
distinct roles during Drosophila neurogenesis. Science, 273: 1227-1231.
>> > *Corresponding author.
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>> > Haddad, G.G., Sun, Y.-A., Wyman, R.J. and Xu, T. (1997). Genetic basis of tolerance to O2 deprivation in Drosophila
melanogaster.  roc. Natl. Acad. Sci. U.S.A. 94:10809-10812.
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>> > Hu, G., Zhang, S., Vidal, M., Ber, J., Xu, T. and Fearon, E.R. (1997). Mammalian homologs of sina (seven in absentia)
regulate DCC via the ubiquitin-proteasome pathway. Genes & Development 11:2701-2714.
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>> > St. John, M.A.R. and Xu, T. (1997). Understanding Human Cancer In A Fly? American Journal of Human Genetics 61:1006-1010.
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>> > Rooke, J.E. and Xu, T. (1998). Positive and negative signals between interacting cells for establishing neuronal fate.
Bioessays, 20:209-214.
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>> > Theodosiou, N.A. and Xu, T. (1998). Use of the FLP-FRT system to study Drosophila development. Methods, 14,355-365.
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>> > Yavari, R, Adida, C., Bray-Ward, P., Brines, M., and Xu, T. (1998). Human Metalloprotease-disintegrin Kuzbanian
Regulates Sympathoadrenal Cell Fate in Development and Neoplasia. Human Molecular Genetics, 7:1161-1167.
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>> > Theodosiou, N. A., Zhang, S., Wang, W. Y., and Xu, T. (1998). slimb coordinates wg and dpp expression in the
dorsal-ventral and anterior-posterior axes during limb development. Development 125, 3411-3416.
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>> > Ma, E., Xu, T., and Haddad, G.G. (1999) Gene regulation by O2 deprivation: an anoxia-regulated novel gene in Drosophila
melanogaster. Molecular Brain Research, 63:217-224.
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>> > Qi, H., Rand, M., Wu, X., Sestan, N., Wang, W., Rakic, P., Xu, T., and Artavanis-Tsakonas, S. (1999). Processing of the
Notch Ligand Delta by the Metalloprotease Kuzbanian. Science, 283:91-94.
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>> > Tao, W., Zhang, S., Turenchalk, G.S., Stewart, R.A., Chang, W., St. John, M.A.R., and Xu, T. (1999). Human homolog of
the Drosophila lats tumor suppressor modulates CDC2 activity, Nature Genetics, 21:177-181.
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>> > St. John, M.A.R., Tao, W., Fei, X., Fukumoto, R., Carcangiu, M.L., Brownstein, D.G., A.F. Parlow, McGrath, J., and Xu,
T. (1999). Mice deficient for Lats1 develop soft tissue sarcomas, ovarian tumors and pituitary dysfunction. Nature
Genetics, 21:182-186.
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>> > Turenchalk, G.S., St. John, M.A.R., Tao, W., and Xu, T. (1999). The role of Lats in cell cycle regulation and
tumorigenesis. Biochimica et Biophysica Acta. 1424:M9-M16.
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>> > Huang, H., Potter, C. J., Tao, W., Li, D.-M., Brogiolo, W., Hafen, E., Sun, H. and Xu, T. (1999). PTEN affects cell
size, cell proliferation and apoptosis during Drosophila eye development. Development 126, 5365-5372.
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>> > Xu, R., Cai, J., Xu, T., Zhou, W., Ying, B., Deng, K., Zhao, S., and Li, C. (1999). Molecular cloning and mapping of a
novel ADAM gene (ADAM29) to human chromosome 4. Genomics. 62: 537-9.
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>> > Rooke, J.E. Wu, X.H. and Xu, T. (1999). Cell Interaction During Neural Development. Investigation on Cell Modulation:
Signal Transduction, Apoptosis, and Gene Expression. Pp.30-35. Ed. Yi, J.S. et al. MMS Press.
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>> > Rooke, J.E., Theodosiou, N.A. and Xu, T. (2000). Clonal analysis in the examination of gene function in Drosophila.
Methods in Molecular Biology 137: Developmental Biology Protocols III, 15-22.
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>> > Wu, X.H., Potter, C.J., Turenchalk, G.S., and Xu, T. (2000). Drosophila Models for Human Diseases. Stem Cells and
Developmental Biology. Ed. Yi, J.S., Sun, P.F., Tung, X.F. and Xu, T. MMS Press.
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>> > Potter, C.J., Turenchalk, G.S., and Xu, T. (2000). Drosophila in cancer research, an expanding role. Trends Genetics,
16:33-39.
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>> > Turenchalk, G.S., Potter, C.J., Haddad, G. and Xu, T. (2001). Drosophila as a genetic model system for understanding
human biology and disease. Genetic Models in Cardiorespiratory Biology Ed. Haddad, G. and Xu, T., Marcel Dekker, Inc.
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>> > Douglas, R.M., Xu, T., and Haddad, G.G. (2001). Hypoxia-sensitive cell cycle checkpoints in Drosophila melanogaster
embryos. Am J Physiol, 280: R1555-R1563.
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>> > Ma, E., Gu, X.Q., Wu, X.H., Xu, T., and Haddad, G.G. (2001). Mutation in RNA editase markedly attenuates neuronal
tolerance to O2 deprivation in Drosophila melanogaster. J Clin Invest, 107:685-693.
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>> > Potter, C. J. and Xu, T. (2001).Mechanisms of Size Control. Current Opinions in Genetics & Development 11:279-286.
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>> > Potter, C. J., Huang, H. and Xu, T. (2001). Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in
regulating cell growth, cell proliferation, and organ size. Cell, 105:357-368.
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>> > Stewart, R., Li, D.M., Huang, H. and Xu, T. (2001). Drosophila C-terminal Src kinase functions upstream of the LATS
tumor suppressor controlling cell proliferation and tissue size. (Nature Genetics, revised).
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>> > Zhang, S., Lee, J. and Xu, T. (2001). The Drosophila Atrophin-1 Homolog Affects Multiple Developmental Processes and
Behaves as a Transcriptional Co-Repressor. (submitted).
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>> > Yang, X.L.. Li, D.M., Chen, W.L., and Xu, T. (2001). Human Homologue of Drosophila lats, LATS1, Suppresses Tumor Cell
Growth by Inducing G2/M Arrest or Apoptosis (Submitted).
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>> > Chen, W.L., Zhang, S., Stewart R. Xu, T. (2001). Ndr Modulates Lats Activity During the Drosophila Development(Submitted).
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>> > Theodosiou, N.A., Huang, H., and Xu, T. (2001). slimb coordinates movement of the morphogenetic furrow. Development
(submitted).
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>> > Books:
>> > Stem Cells and Developmental Biology. Ed. Yi, J.S., Sun, P.F., Tung, X.F. and Xu, T. M. M. S. Press. (2000).
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>> > Genetic Models in Cardiorespiratory Biology. Ed. Haddad, G. and Xu, T., Marcel Dekker, Inc. (2001).
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