A Postdoctoral position is available for an electrophysiologist with interest in molecular biology in Dr. Zhengping Jia’s laboratory, Department of Physiology, University of Toronto; Neurosciences & Mental Health, The Hospital for Sick Children; Toronto, Canada. The primary assignment of this postdoctoral position would be studies of hippocampal synaptic plasticity on various strains of transgenic mice. Techniques include whole-cell recordings and molecular manipulations such as viral vector-mediated gene expression. http://www.sickkids.ca/HSCdirectory/personalprofile.asp?pID=3715&s=Research+Programs&sID=1104&ss=Neurosciences+%26+Mental+Health&ssID=378&sss=&sssID= http://www.uoftphysiology.com/faculty/members/facultyDetails.cfm?faculty=39&from=facultyList Select publications: Meng J, Meng Y, Hanna A, Janus C, Jia Z. Abnormal long-lasting synaptic plasticity and cognition in mice lacking the mental retardation gene Pak3. J Neurosci. 2005 Jul 13;25(28):6641-50. Meng Y, Zhang Y, Tregoubov V, Falls DL, Jia Z. Regulation of spine morphology and synaptic function by LIMK and the actin cytoskeleton. Rev Neurosci. 2003;14(3):233-40. Review. Meng Y, Zhang Y, Jia Z. Synaptic transmission and plasticity in the absence of AMPA glutamate receptor GluR2 and GluR3. Neuron. 2003 Jul 3;39(1):163-76. Meng YH, Zhang Y, Tregoubov V, Janus C, Cruz L, Jackson M, Lu WY, MacDonald JF, Wang J, Falls DL, Jia ZP. Abnormal spine morphology and enhanced LTP in LIMK-1 knockout mice. Neuron. 35: 121-133, 2002. Peng X, Jia ZP, Zhang Y, Ware J, Trimble, W. The septin CDCrel-1 is dispensable for normal development and neurotransmitter release. Molecular and Cellular Biology. 22 (1): 378-387, 2002. Henderson J, Georgiou J, Jia ZP, Robertson J, Elowe S, Roder J, Pawson T. The receptor tyrosine kinase EphB2 regulates NMDA-dependent synaptic function. Neuron. 32: 1041-1056, 2001. Lei S, Jackson M, Jia ZP, Roder J, Bai D, Orser BA, MacDoanld JF. Cyclic GMP-dependent feedback inhibition of AMPA receptors is independent of PKG. Nature Neuroscience. 3(6):559-565, 2000. Gerlai R, Henderson J, Roder J, Jia ZP. Multiple behavioral anomalies in GluR2 mutant mice exhibiting enhanced LTP. Behav. Brain Res. 95(1):37-45, 1999. Jia ZP, Lu Y-M, Henderson J, Taverna F, Romano C, Abramow-Newerly W, Wojtowicz M, Roder J. Selective abolition of the NMDA component of long term potentiation in mice lacking mGluR5. Learning & Memory. 5: 331-343, 1998. Mainen ZF, Jia ZP, Roder J, Malinow R. Use-dependent AMPA receptor block in mice lacking GluR2 suggests postsynaptic site for LTP expression. Nature Neuroscience. 1(7):579-586, 1998. Jia ZP, Agopyan N, Miu P, Xiong Z, Henderson J, Gerlai R, Taverna F, Velumian A, MacDonald J, Carlen P, Abramow-Newerly W, Roder J, Enhanced LTP in mice deficient in the AMPA receptor GluR2. Neuron. 17:945-956, 1996. Hahnenberger KM, Jia ZP, Young PG. Functional expression of the Schizosaccharomyces pombe Na+/H+ antiporter gene, sod2, in saccharomyces cerevisiae. PNAS USA. 93, 5031-5036, 1996. Jia ZP, McCullough N, Martel R, Hemmingsen S, Young PG. Gene amplification at a locus encoding a putative Na+/H+ antiporter confers sodium and lithium tolerance in fission yeast. EMBO J. 11: 1631-1640, 1992. |