关于记忆巩固（consolidation）的统一理论

Review
A unified theory for systems and cellular memory consolidation
Pramod K. Dash*, April E. Hebert, Jason D. Runyan
The Vivian L. Smith Center for Neurologic Research and the Department of Neurobiology and Anatomy, The University of Texas Medical School,
P.O. Box 20708, Houston, TX 77225, USA
Accepted 19 February 2004
Abstract
The time-limited role of the hippocampus for explicit memory storage has been referred to as systems consolidation

where learningrelated changes occur first in the hippocampus followed by the gradual development of a more distributed

memory trace in the neocortex. Recent experiments are beginning to show that learning induces plasticity-related

molecular changes in the neocortex as well as in the hippocampus and with a similar time course. Present memory

consolidation theories do not account for these findings. In this report, we present a theory (the C theory) that

incorporates these new findings, provides an explanation for the length of time for hippocampal dependency,

and that can account for the apparent longer consolidation periods in species with larger brains.

This theory proposes that a process of cellular consolidation occurs in the hippocampus and in areas of the

neocortex during and shortly after learning resulting in longterm memory storage in both areas. For a limited time,

the hippocampus is necessary for memory retrieval, a process involving the coordinated reactivation of these

areas. This reactivation is later mediated by longer extrahippocampal connectivity between areas. The delay

in hippocampal-independent memory retrieval is the time it takes for gene products in these longer extrahippocampal

projections to be transported from the soma to tagged synapses by slow axonal transport. This cellular transport

event defines the period of hippocampal dependency and, thus, the duration of memory consolidation.

The theoretical description for memory consolidation presented in this review provides alternative explanations

for several experimental observations and presents a unification of the concepts of systems and cellular memory

consolidation.
www.elsevier.com/locate/brainresrev
Brain Research Reviews 45 (2004) 30– 37

［此帖子已被 remind_me 在 2004-9-30 8:30:58 编辑过］

复制出来排版太差了，有兴趣到 science direct 上去看吧，Brain Research Reviews 45 (2004) 30– 37。

这篇文章是个综述（review），介绍神经科学的关于长时记忆巩固的很多知识。看完文章，对记忆形成有关的部位，过程，细胞等底层机制都会有深入的了解。结合最新的试验发现，文章提出了新的理论，很有意思。

［此帖子已被 remind_me 在 2004-9-28 10:00:50 编辑过］

标题应该是，consolidation ，敲错了，怎么改？

点贴子的下面 编辑 按纽