Xueliang Zhu

Curriculum vitae



Name:              Xueliang Zhu

Degree:              h. D

Title:                    rofessor

Date of birth:            February 7, 1963

Place of birth:      Chuxiong, Yunnan Province, China

Position:            Research group leader; assistant director

Affiliation:            Institute of Biochemistry and Cell Biology,

Chinese Academy of Sciences

Mailing address:      Shanghai Institute of Biochemistry and Cell Biology,

320 Yue Yang Road,

Shanghai 200031,

China

Phone:              (o) 86-21-64315030 ext. 2156

Fax:                    86-21-64331090

E-mail:            xlzhu@sunm.shcnc.ac.cn



B. Sc. (1985) and M. Sc. (1988), University of Science and Technology of China, USTC; Ph.D. (1995), Shanghai Institute of Cell Biology, Chinese Academy of Sciences (CAS).  Associate professor since 1997.  rofessor since 1999.
 

Previous Appointments and experiences

Biologist Scientist in Lawrence Berkeley National lab, UC, Berkeley, USA (2001. 03-2001. 08). Group leader in Shanghai Research Center of Life Sciences, Chinese Academy of Sciences (1997-1999).  ost-doctoral fellow and group leader in Shanghai Research Center of Life Sciences (1995-1997).  Lecturer in Department of Biology, USTC (1995). Exchange visiting scholar for Ph. D. dissertation in Institute of Biotechnology, University of Texas Health Science Center at San Antonio, USA (1991-1994), and in Department of Pathology, University of California at San Diego, USA (1990-1991). Assistant lecturer and lecturer in Department of Biology, USTC (1988-1990).



Research interest

I am interested in the regulatory protein networks in the cell cycle, especially in mitosis. What attracts us is the complexity and precision of the spindle checkpoint, a mechanism that guarantees precise separation of chromosomes during mitosis. Since abnormal mitosis is associated with genetic instability, cell death, cancer, and other congenital defects, understanding the molecular aspects of this checkpoint is one of the most exciting and important frontiers in cell biology.  In addition, part of our work is focused on regulation of asymmetrical mitosis, a process required for proper maintenance of many stem cells in animals.  We are also interested in cell motility and vesicle trafficking in which motor proteins important for mitosis also play roles.
 

Publications (*: Corresponding author):

1.      Fan L, Yu W, and X. Zhu* (2003). Interaction of Sedlin with chloride intracellular channel proteins. FEBS Lett. (in press).

2.      Yan X, Li F, Liang Y, Shen Y, Zhao X, Huang Q, and X. Zhu *. (2003). Human Nudel and NudE as Regulators of Cytoplasmic Dynein in Poleward Protein Transport along the Mitotic Spindle. Mol. Cell. Biol. 23(4):1239-50.

3.      Qian, M., Dou, Z., Gu, Y., Zhang, Q., Lu, R., and X. Zhu* (2002). Cloning and analysis of highly repetitive sequence fragments from takin (Budorcas taxicolor). Acta Biol. Exp. Sinica 35 (1):36-41.

4.      Zhao, X., Yang, Z., Qian, M., and X. Zhu* (2001). Interaction among subunits of human Arp2/3 complex: p20-Arc as the hub. Biochem. Biophy. Res. Commun. 280：513-517.

5.      Yan, X., Zhao, X., Qian, M., Guo, N., Gong, X., and Zhu, X.* (2000). Characterization and gene structure of a novel retinoblastoma-protein-associated protein similar to the transcription regulator TFII-I. Biochem. J.  345:749-757.

6.      Zhu,X.* (1999). Structural requirements and dynamics of mitosin-kinetochore interaction in M phase.  Mol. Cell. Biol. 19 (2):1016-1024.

7.      Zhu, X.*, Ding, L., and Pei, G. (1997). The carboxyl terminus of mitosin is sufficient to confer spindle pole localization.  J. Cell. Biochem. 66:441-449.

8.      Zhu, X., Wang, C., Cheng, Z., Wu, Y., Zhou, D., and Pei, G. (1997). The carboxyl terminus of mouse -opioid receptor is not required for agonist-dependent acitivation. Biochem. Biophy. Res. Commun. 232:513-516.

9.      Xu, X., Wang, Y., Wei, C., and Zhu, X. (1996). Study on the action mechanism of Hemorrhagin I from Agkistrodon acutus venom. Adv. Exp. Med. Biol. 391:361-366.

10.      Zhu, X., Chang, K.-H., He, D., Mancini, M. A., Brinkley, W. R., and Lee, W.-H. (1995). The C-terminus of mitosin is essential for its nuclear localization, centromere/kinetochore targeting, and dimerization.  J. Biol. Chem.  270(33): 19545-19550.

11.      Zhu, X., Mancini, M. A., Chang, K.-H., Liu, C.-Y., Chen, C.-F., Shan, B., Jones, D., Yang-Feng, T. L., and Lee, W.-H. (1995). Characterization of a novel 350-kDa nuclear phosphoprotein that is specifically involved in mitotic-phase progression. Mol. Cell. Biol. 15(9): 5017-5029.

12.      Shan, B., Zhu, X., Chen, P.-L., Durfee, T., Yang, Y., Sharp, D., and Lee, W.-H. (1992). Molecular cloning of cellular genes encoding retinoblastoma-associated proteins: Identification of a gene with properties of the transcription factor E2F. Mol. Cell. Biol. 12, 5620-5631.

13.      Zhu, X., Wang, Y., Huang, Z., Liu, J., Cui, T., Huang, W., Niu, L., and Xun, X. (1992) Molecular cloning of D-xylose isomerase from Streptomyces M1033. Chinese J. of Biotech.  8(3): 232-236.