http://chin.csdl.ac.cn/SPT--FullRecord.php?ResourceId=6884 Professor Barton has pioneered the application of transition metal complexes as tools to probe recognition and reactions of double helical DNA. Using chiral coordination complexes, matching their shapes, symmetries, and functionalities to sites along the strand, she has designed octahedral metal complexes which recognize nucleic acid sites with affinities and specificities rivaling DNA-binding proteins. These synthetic transition metal complexes have been useful in elucidating fundamental chemical principles which govern the recognition of nucleic acids, in developing luminescent and photochemical reagents as new diagnostic tools, and in laying a foundation for the design of novel chemotherapeutics and biosensors. With these transition metal probes, she has also carried out seminal studies to elucidate electron transfer chemistry mediated by the DNA double helix. This work provides a completely new approach to the study of DNA structure and dynamics and may be critical to understanding the chemical consequences of radical damage to DNA within the cell. 楼上看看吧,反正我不懂 |