内毒素(Cholera toxin)

Cholera toxin
Cell Culture Reagents-Growth Supplements


Catalogue Number: CC104
Description: Toxin consisting of an A subunit (27 kDa) with five B subunits (approximately 12 kDa each) surrounding, which attach the toxin to ganglioside GM1 on the cell surface. The A subunit catalyzes ADP-ribosylation of the α-subunit of the stimulatory G protein (Gαs), reducing GTPase activity and activating the α-subunit. This activation of Gαs leads to an increase in the activity of adenylyl cyclase, resulting in increased levels of cAMP. Cholera toxin has also been reported to ADP-ribosylate tubulin. Shown to be a potent mucosal vaccine adjuvant, inducing T helper cell type 2 responses by inhibiting the production of interleukin-12.
Physical Appearance: Sterile filtered clear solution.
Formulation: 50g/ml solution.
Pack Size: 1.0 mL
Stability: Stored at -20°C. Please avoid freeze-thaw cycles.
Suitability: Cell culture tested.