Min Zhuo

Curriculum Vitae -- , Ph.D.





Date:            July 29, 2003



Min Zhuo, Ph.D.



Department of Physiology, University of Toronto, 1 Kings College Circle, Toronto, Ontario, Canada, M5S 1A8



Personal Information:

     lace of Birth:      Xiapu, Fujian, P.R. China

     Citizenship: USA



Present Position:      rofessor of Physiology

Smith Chair in Neuroscience

                 Canadian Research Chair, Tier I



EDUCATION

     Undergraduate:

     1985            University of Science & Technology, Anhui, China

                 B.S., Physiology & Biophysics.

     Graduate:

1987            Shanghai Institute of Physiology, Graduate program, Shanghai, China

     1988 - 1989      Visiting Scientist, University of Iowa, Supervisor: G.F. Gebhart

1989 - 1992      redoctoral Fellow, University of Iowa, Supervisor: G.F. Gebhart

1992            University of Iowa, Ph.D., Pharmacology.

     

     ostgraduate:

1992 - 1993      ostdoctoral Fellow, Columbia University, Supervisor: E.R. Kandel (Nobel Laureate)

1993 - 1995      Research Associate, Howard Hughes Medical Institute,  Columbia

                 University, Supervisor: E.R. Kandel (Nobel Laureate)

1995 - 1996      ostdoctoral Fellow, Stanford University, Supervisor: R. W. Tsien

     

APPOINTMENTS

     1996, July – 1999, December      Assistant Professor, Department of Anesthesiology

Assistant Professor, Department of Anatomy and Neurobiology

     2000, January-2002, June      Associate Professor, Department of Anesthesiology

Associate Professor, Department of Anatomy and Neurobiology

Associate Professor, Department of Psychiatry

2000, January-present            Chief of Basic Research, Washington University Pain Center

2002, June-2003, June      rofessor, Department of Anesthesiology

Professor, Department of Anatomy and Neurobiology

Professor, Department of Psychiatry

     2003, July-present            rofessor, Department of Physiology, University of Toronto

                             Smith Chair in Neuroscience, EJLB-CIHR

                             Canadian Research Chair, Tiger I



RESEARCH INTEREST

Genetic models for neurological and psychiatric diseases

Synaptic transmission and regulation

Retrograde messengers

Synaptic plasticity: long-term potentiation and depression

Physiological and pathological related central plastic changes: synaptic responses and action potentials

Memory, emotion, sensation, stress and cortical reorganization

Alzheimer’s disease, aging and persistent pain



FELLOWSHIPS AND HONORS

     Travel Award, American Pain Society, 1990, 1991, 1992

     Travel Award, International Association for the Study of Pain, 1991

     Howard Hugh Medical Institute postdoctoral fellowship (1993-1995)

     NIH research Career Development Award (R29, 1997-2001)

     Wang Kuan-Cheng Research Award  (2003)

     Smith Chair in Neuroscience (2003-2008)

     Canadian Research Chair, Tier I (2003-2010)



EDITORIAL BOARDS AND ACTIVITES

Editor: Acta Physiologica Sinica, China



Ad Hoc Reviewer:

Nature; Neuron; Journal of Neuroscience; Journal of Physiology (London); Journal of Neurophysiology; Trends in Neuroscience; Neuroscience; Molecular and Cellular Neuroscience; Neuropharmacology; Cellular and Molecular Life Sciences; Journal of Pain; Pain; Current Medicinal Chemistry; Anesthesiology; Brain Research; Life Sciences; Molecular Brain Research; Somatosensory Research; Experimental Brain Research, Brain Research Bulletin, NeuroSignals, Biological Sciences of Nursing



Grant reviewer

NIH, National Institutes of Neurological Disorders and Stroke Special Emphasis Panel, ZNS1 SRB W1 (June 21-22, 1999)

Reviewer of JIF applications: The Wellcome Trust, UK (1999)

NIH, National Institutes of Neurological Disorders and Stroke, NSD-C Review committee (June 12-13, 2000)

Reviewer of CRDF in pain (Civilian Research & Development Foundation) (2000)

NIH, National Institutes of Neurological Disorders and Stroke, NSD-C Review committee (February 12-13, 2001)

Reviewer of CRDF in memory (Civilian Research & Development Foundation) (2001)

Organizer of Midwest Pain Interest Group meeting in St Louis (2001)

Reviewer for the John Sealy Memorial Endowment Fund for Biomedical Research, The University of Texas Medical Branch, Galveston (2002).

Reviewer for National Natural Science Foundation of China, Life Science proposals (2002)

Reviewer of The Wellcome Trust, UK (2003)

Reviewer for the John Sealy Memorial Endowment Fund for Biomedical Research, The University of Texas Medical Branch, Galveston (2003).



Referee and evaluation of tenured professor or the promotion to Full professor

2002, University of Toronto, University of Florida, University of Cincinnati

2003, Baylor College of Medicine, John Hopkins University, Georgia State University



PROFESSIONAL SOCIETIES AND ORGANIZATIONS

Society for Neuroscience

American Pain Society

International Association for the Study of Pain

American Association for the Advancement of Science



RECENT INVITED PROFESSORSHIPS AND LECTURESHIPS

Chairs and Speaker

1999, Speaker, August.  International Association for the Study of Pain meeting, Workshop on “Descending modulation of nociception in animal models of persistent pain”, Vienna.

1999, Speaker, September, Conference on Neuronal circuits: from molecules to organisms, Ascona, Switzerland.

2001, Speaker, September.  Cambridge Healthtech Institutes’s Third Annual “Application of Genomics to Animal models for pharmaceutical studies”, Boston, USA.

2002, Speaker, May.  International symposium on plasticity of pain system, Fukuoka, Japan.

2002, Speaker, June, C.N.R.S. - Jacques Monod Conference; "Glutamate receptors and transporters: structure, cell biology, physiology.” France.

2002, Speaker, April, Spring Pain meeting (Grand Cayman), Kainate receptors and pain, Grand Cayman.

2003, Speaker, March, Dinner symposium, American Pain Society Annual meeting. “Cortical plasticity after amputation”. Chicago, USA

2003, Speaker, April, British Neuroscience Meeting. “Glutamate subtype receptors: from sensory transmission & modulation to chronic pain”, UK

2003, Speaker and co-organizer, April, The 5th East-West Pain Conference, Anhui, The Yellow mountain, China

2003, September, Novaris Foundation Symposium: Pathological pain from molecular to clinical aspects, Tsukuba, Japan

2004, Speaker, August, Beijing, China, NorthAmerican Chinese neuroscientists meeting, Speaker for Synaptic plasticity (delayed)

2004, Co-Chair and speaker, August, 16th International Congress of IFAA (International Federation of Association of Anatomists), Kyoto, Japan,: The Progress of Pain Research in Anatomy and Physiology.

2004, Chair and Speaker, Spring Pain meeting (Grand Cayman), Glutamateric synapses in pain transmission and plasticity, Grand Cayman.



University Seminar speaker

1998, Neuroscience weekend seminar, Washington University

1998, Department of Neurology, Washington University

1998, Pain Management Seminar, Washington University

1999, October, Center for Basic Neuroscience, University of Texas, Southwestern Medical Center at Dallas.

2000, February, Indiana University, Department of Anatomy and cell biology.

     2000, May, The Rockefeller University, Paul Greengard’s laboratory.

2000, May, Department of Anesthesiology resident lecture: Mechanism of Pain Transmission and Modulation.  

     2000, June, Midwest Pain Interesting Group meeting, Iowa City.

     2000, September, Department of Cell Biology, Washington University

     2000, October, Department of Anatomy and Neurobiology, Washington University

     2001, September, University of Cincinnati, Neuroscience program Speaker.

2001, September, Department of Anesthesiology Grand Round speaker, Washington University.

2001, September, Pain Management seminar speaker, Washington University.

2001, October, Department of Psychiatry, Grandround Speaker, Washington University

2002, March, University of Iowa, Pain program Speaker.

2002, May, Department of Pharmacology, Kyoto University, Japan.

2002, July, University of Toronto, Department of Physiology and the Centre of Pain Studies, Canada. “Synaptic and genetic analyses of pain and memory: from synapse to behaviour”

2002, September, Baylor College of Medicine, Neuroscience program seminar

2002, November, John Hopkins University, Pain research program

2003, February, University of Texas at Galveston, Department of Neuroscience

2003, September, University of British Columbia, Brain Research Institute, “Synaptic connections: from pain to memory”



Pharmaceutical companies and consulters

2001, October, Pharmacia seminar Speaker, Chicago, USA.

2002, May, Pfizer Inc., Global Research & Development, Nagoya, Japan.  

2003, June, Purdue Pharma Inc, New Jersey, USA.

2003-2004, Pfizer Inc., Global Research & Development, Nagoya, Japan.



STUDENTS AND POSTDOCTORAL FELLOWS SUPERVISED



Undergraduate students

Michael H.C. Ch’ang-(1997)                      Undergraduate student, in business school now.

     Kalana S. Thomas –(1997-1998)                Undergraduate student

     Susan J. Kim-(1997-2000)                          Undergraduate student

Don Evans Lee-(1997-1998)                       Undergraduate student, in medical school.

Amelita A. Calejesan-(1998-2001)         HHMI undergraduate fellows, accepted by the medical school in University of Pittsburgh, full fellowship

Jason Liauw-(1999-2003)               Undergraduate student, accepted by Stanford University medical school

     Michael Rowley (2000-2003)      Undergraduate student

     Lydia Stephenson (2002-2003)      Undergraduate student, applying for medical school

     Collete Sim (2000-2003)      Undergraduate student



Graduate students:

Geoffrey A. Kerchner-(1999-2001)           M.D. and Ph. D. program, Graduated as

Spencer T. and Ann W. Olin medical fellow (due to his excellent thesis work); Resident training in UCSF

     Daphne A. Robinson-(1999-2003)          Neuroscience program Ph.D., Post-doc in NIH, NINDS

     Shanelle Ko (2001-present)      Molecular Genetic program Ph.D. candidate

     Francesco, Nodari (2002-2003)      Neuroscience program Ph.D. candidate      



Postdoctoral fellows

     Guo-Du Wang-(1999-2001)      ostdoc.  Research Assistant Professor in Ohio State University

Feng Wei-(1998-2002)           Postdoc.  Assistant Professor, University of Maryland

Jiangrong Tang (2002-2003)      ostdoctoral fellow, Baylor College of Medicine

Hushun Ao (2002-2003)                  Postdoctoral fellow, HHMI and Washington University



Research assistants

Ping Li-(1996-2002)               On medical leave.

Changshan Qiu (2000-2003)      Emory University



RESEARCH SUPPORT:

     Government:

           NIH/NIA   5 P50 AG 05681-14 - Alzheimer’s Disease Research Center

           Principal Investigator - Pilot Project 15

           A cellular model for aging-related memory loss      

           6/15/97-4/30/98      $20,000 (DC)



           NIH/NIDA  5 R29-DA-10833-02

           Principal Investigator - FIRST Award

           Descending Biphasic Modulation in Persistent Pain

           1/10/97-11/30/01      $325,698 (DC)



           NIH/NINDS 1 R01 NS38680-01

           Principal Investigator

           Serotonergic regulation of sensory transmission

           6/05/99-3/31/03      $1,163,042 (DC)



Role: Co-Investigator

NIH/ADRC

P50 AG05681  Bu (PI)      

Role of LRP and its Ligand tPA in LTP and Aging

The major goals of this proposal are to investigate the molecular mechanisms by which LRP and its ligand tPA regulate L-LTP, and to examine the expression of these molecules during aging and AD.

Role: Co-Investigator

04/01/00 – 03/31/05



     Non Government:

Muglia (PI)      

McDonnell Center for Higher Brain Function

Adenylyl cyclases in stress adaptation

In this proposal we seek to define the role of AC8 in transduction of stress-induced signals important for hippocampal LTD and alterations in behavior.

07/01/00 – 06/30/03



Washington University - McDonnell Center for Higher Brain Function

           Principal Investigator

           Role of cingulate cortex in long-term hyperalgesia after amputation

           7/01/97-6/30/99      $60,000 (DC)



           Washington University-Monsanto Biomedical research support program

           Principle Investigator

           Role of opiates and clyclooxygenases in chronic pain

           1/1/2000-12/31/2001          $224,000 (DC)



TEACHING TITLE AND RESPONSIBILITIES:

     Special Topic in the Medical Neuroscience course:  Neurobiology of nociception and pain  (1998)

     Specific Topic in Cellular Biology: Cellular Basis of Nociception and Pain (1999, 2000, 2001) for medical and graduate students

     Neuroscience qualifying examination (2000-2003)      

     Cellular mechanisms for memory and pain (2002; 2003)

PUBLICATIONS (1989-present)



Research articles



1.      Chiang CY, Zhuo M (1989).  Evidence for the involvement of descending cholinergic pathway in systemic morphine analgesia. Brain Research, 478:293-300.



2.      Zhuo M, Gebhart GF (1990).  Spinal cholinergic and monoaminergic receptors mediate descending inhibition from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat.  Brain Research, 535:67-78.



3.      Zhuo M, Gebhart GF (1990).  Characterization of descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Pain, 42:337-350.



4.      Zhuo M, Gebhart GF (1991).  Tonic cholinergic inhibition of spinal mechanical transmission. Pain, 46:211-222.



5.      Zhuo M, Gebhart GF (1991).  Spinal serotonin receptors mediate descending inhibition and facilitation from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. Brain Research, 550:35-48.



6.      Zhuo M, Gebhart GF (1992).  Inhibition of a cutaneous nociceptive reflex by a noxious visceral stimulus is mediated by spinal cholinergic and descending serotonergic systems in the rat. Brain Research, 585:7-18.



7.      Zhuo M, Gebhart GF (1992).  Characterization of descending facilitation and inhibition of spinal nociceptive transmission from the nuclei reticularis gigantocellularis and gigantocellularis pars alpha in the rat. J. Neurophysiology, 67:1599-1614.



8.      Zhuo M, Meller ST, Gebhart GF (1993).  Endogenous nitric oxide is required for tonic cholinergic inhibition of spinal mechanical transmission. Pain, 54:71-78.



9.      Ren D, Zhuo M, Randich A, Gebhart GF (1993).  Vagal afferent stimulation produced effects on nociception in neonatal capsaicin-treated rats.  J. Neurophysiology, 69:1530-1540.



10.      Zhuo M, Small SA, Kandel ER, Hawkins RD (1994).  Nitric oxide and carbon monoxide produce activity-dependent long-term synaptic enhancement in hippocampus. Science, 260:1946-1950.



11.      Zhuo M, Gebhart GF (1994).  Effects of neonatal capsaicin treatment of descending modulation of spinal nociception from the rostral, medial medulla in adult rat. Brain Research, 645:164-178.



12.      Zhuo M, Hu Y, Schultz C, Kandel ER, Hawkins RD (1993).  Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation in hippocampus. Nature, 368:635-639.



13.      Zhuo M, Kandel ER, and Hawkins RD (1994).  Nitric oxide and cGMP produce either synaptic depression or potentiation depending on the frequency of presynaptic stimulation in hippocampus. NeuroReport, 5:1033-1036.



14.      Brandon EP, Zhuo M, Huang Y-Y, Qi M, Kandel ER, Mcknight GS, Idzerda RL (1995).  Hippocampal long-term depression and depotentiation require the RI regulatory subunit of PKA. Proc. Natl. Acad. Sci. USA, 92:8851-8855.



15.      Qi M, Zhuo M, Skalhegg BS, Brandon EP, Kandel ER, McKnight GS, Idzerda RL (1996).  Impaired hippocampal plasticity in mice lacking the C-1 catalytic subunit of CAMP-dependent protein kinase. Proc. Natl. Acad. Sci. USA, 93:1571-1576.



16.      Huang YY, Bach ME, Lipp HP, Zhuo M, Wolfer DP, Hawkins RD, Schoonzans, Kandel ER, Godfraind JM, Mulligan R, Coller D, Carmeliet P (1996).  Mice lacking the gene encoding tissue-type plasminogen activator show a selective interference with late phase LTP in both schaffer collateral and mossy fiber pathways. Proc. Natl. Acad. Sci. USA, 93:8699-8704.



17.      Zhuo M, Gebhart GF (1997).  Biphasic modulation of spinal nociceptive transmission from the medullary raphe nuclei in the rat.  J. Neurophysioogy, 78:746-758.



18.      Kavalali ET, Zhuo M, Bito H, Tsien RW (1997).  Dendritic Ca2+ channels characterized by recordings from isolated hippocampal dendritic segments. Neuron, 18:651-663.



19.      Son, H, Lu, Y-F, Zhuo, M, Arancio, O, Kandel, ER, Hawkins, RD (1998).  The specific role of cGMP in Hippocampal LTP.  Learning & Memory, 5:231-245.  



20.      Zhuo, M, Laitinen, JT, Li, X-C, Kandel, ER, Hawkins, RD (1998).  Tests of the roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus.  Learning & Memory, 5:467-480.



21.      Li, P, Calejesan, AA, Zhuo, M (1998).  ATP P2X receptors and sensory transmission between primary afferent fibers and spinal dorsal horn neurons in rats.  J. Neurophysiol. 80:3356-3360.



22.      Li, P, Zhuo, M (1998).  Silent glutamatergic synapses and nociception in mammalian spinal cord. Nature, 393:695-698.



23.      Zhuo, M (1998).  NMDA receptor-dependent long term hyperalgesia after tail amputation. Eur. J. Pharmacol. 349:211-220.



24.      Calejesan, AA, Ch’ang, MH-C and Zhuo, M (1998).  Spinal serotonergic receptors mediate facilitation of a nocieceptive reflex by subcutaneous formalin injection into the hindpaw in rats. Brain Research, 798:46-54.



25.      Kim, SJ, Thomas, KS, Calejesan, AA and Zhuo, M (1998).  Macromolecular syntheses contributes to nociceptive response to subcutaneous formalin injection in mice.  Neuropharmacology, 37:1091-1093.



26.      Zhuo, M, Zhang, W, Son, H, Mansuy, I, Sobel, RA, Seidman, J, Kandel, ER (1999).  A selective role of calcineurin A in synaptic depotentiation in hippocampus.  roc. Nat’l. Acad. Sci. USA, 96:4650-4655.



27.      Bach, ME, Barad, M., Son, H, Zhuo, M, Lu, Y-F, Shih, R, Kandel, ER, Hawkins, RD (1999).  Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated by drugs that enhance the cAMP signaling pathway. Proc. Nat’l. Acad. Sci. USA, 96:5280-5285.



28.      Kim, S.J., Calejesan, A.A., Li, P., Wei, F. and Zhuo, M (1999).  Sex differences in late behavioral response to subcutaneous formalin injection in mice.  Brain Research, 829:185-189.



29.      Li, P, Wilding, TJ, Kim, SJ, Calejesan, AA, Huettner, JE, Zhuo, M (1999).  Kainate receptor-mediated sensory synaptic transmission in mammalian spinal cord.  Nature, 1999, 397:161-164.



30.      Tang, YP, Shimizu, E., Dube, G., Rampon, C., Kerchner, G.A., Zhuo, M., Liu, G. and Tsien, J.Z (1999).  Genetic enhancement of learning and memory in mice.  Nature, 401:63-69 (Comment in: Nature. 1999 Sep 2;401(6748):25-7).



31.      Li, P, Kerchner, G.A., Sala, C., Wei, F., Huettner, JE, Sheng, M. and Zhuo, M (1999).  AMPA receptor-PDZ protein interaction mediate synaptic plasticity in spinal cord.  Nature Neuroscience, 1999, 2:972-977.



32.      Wei, F., Li, P. and Zhuo, M (1999).  Loss of synaptic depression in mammalian anterior cingulate cortex following amputation.  J Neuroscience, 19:9346-9354.



33.      Lee, D.E., Kim, S.J. and Zhuo, M (1999).   Comparison of behavioral responses to noxious cold and heat in mice.  Brain Research, 845:117-121.



34.      Azpiazu, I., Cruzblanca, H., Li, P., Linder, M., Zhuo, M. and Gautam, N (1999).  A G protein  subunit-specific peptide inhibits muscarinic receptor signaling.   J Biol Chem.  274:35305-35308.



35.      Zhuo, M., Holtaman, D.M., Li, Y., Demaro, J., Jacquin, M. and Bu, G (2000).  Role of tissue-type plasminogen activator receptor LRP in hippocampal long-term potentiation. J Neuroscience, 20:542-549.



36.      Calejesan, A.A., Kim, S.J., Zhuo, M (2000).  Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex.  Eur J Pain,  4:83-96.



37.      Schaefer, M.L., Wong, S.T., Wozniak, D.F., Muglia, L.M., Liauw, J.A., Zhuo, M., Nardi, A., Hartman, R.E., Vogt, S.K., Luedkel, C.E., Storm, D.R. and Muglia, LJ (2000). Altered stress-induced anxiety in adenylyl cyclase type VIII-deficient mice.  J Neuroscience, 20:4809-4820.



38.      Wei, F., Xu, Z.C., Qu, Z., Milbrandt, J. and Zhuo M (2000).  Role of Egr1 in hippocampal synaptic enhancement induced by tetanic stimulation and amputation.  Journal of Cell Biology, 149:1325-1333.



39.      Feng, J., Yan, Z., Ferreira, A., Tomizawa, K., Liauw, J.A., Zhuo, M., Allen, P.B., Ouimet, C.C. and Greengard, P (2000).  Regulation of the formation and function of dendritic spines by spinophilin. Proc. Nat’l. Acad. Sci. USA, 16:9287-9292.



40.      Nga Ho, Jason A. Liauw, Frank Blaeser, Feng Wei, Silva Hanissian, Lisa M. Muglia, David F. Wozniak, Anthony Nardi, David J. Linden, Min Zhuo, Louis J. Muglia, Talal A. Chatila (2000).  Impaired Synaptic Plasticity and CREB Activation in CaMKIV/Gr-deficient Mice. J Neuroscience, 20:6459-6472.  



41.      Kerchner, G.A., Wilding, T.J., Li, P., Zhuo, M and Huettner, JE (2001).  resynaptic kainate receptors regulate spinal sensory transmission. J Neuroscience, 21:59-66.  



42.      Wei, F., Wang, G.-D., Kerchner, G.A., Kim, S.J., Xu, H.-M., Chen, Z.-F. and Zhuo, M (2001).  Genetic enhancement of persistent pain by forebrain NR2B overexpression.  Nature Neuroscience, 4:164-169 (Comment in: The Lancet, 357:367, 2001; Nature Press Release).  



43.      Wei, F. and Zhuo, M (2001).  otentiation of synaptic responses in the anterior cingulate cortex following digital amputation in rat.  J Physiology (Lond), 532:823-833.



44.      Li, P. and Zhuo, M (2001).  Cholinergic, noradrenergic and serotonergic inhibition of fast synaptic transmission in spinal lumbar dorsal horn of rat.  Brain Research Bulletin, 54:639-647.



45.      Kerchner, G.A., Wei, F., Wang, G.-D., Kim, S.J., Xu, H.-M., Robinson, D.A., Li, P., Chen, Z.-F. and Zhuo, M (2001).  DO ‘smart’ mice feel more pain, or are they just better learners?  Nature Neuroscience, 4:453-454.



46.      Li, P. and Zhuo, M (2001).  Substance P and neurokinin A mediate sensory synaptic transmission in young rat dorsal horn neurons.  Brain Research Bulletin, 55:521-531.



47.      Kerchner, G.A., Wang, G.D. and Qiu, C.-S., Huettner, J.E. and Zhuo, M (2001).  Direct presynaptic regulation of GABA/Glycine release by kainate receptors in the dorsal horn: an ionotropic mechanism.  Neuron, 32:477-488 (Comment in: Neuron. 2001 Nov 8;32(3):376-8.)



48.      Wang, G.-D. and Zhuo, M (2002).  Synergistic enhancement of glutamate-mediated responses by serotonin and forskolin in adult mouse spinal dorsal horn neurons. J Neurophysiology 87:732-739.



49.      Zhuo, M. and Gebhart G.F (2002).  Biphasic modulation of a visceral nociceptive reflex from the rostroventral medial medulla in the rat.  Gastroenterology, 122:1007-1019.  



50.      Zhuo M, Sengupta, J.N. and Gebhart GF (2002).  Biphasic modulation of spinal visceral nociceptive transmission from the rostroventral medial medulla in the rat.  J Neurophysiology, 87:2225-2236.



51.      Robinson DA, Wei F, Wang GD, Li P,  Kim SJ, Vogt SK, Muglia LJ, Zhuo M (2002).  Oxytocin mediates stress-induced analgesia.  J Physiology (Lond), 540:593-606.



52.      Wei F, Qiu CS, Liauw J, Robinson DA, Ho N, Chatila T, Zhuo M (2002).  Calcium calmodulin-dependent protein kinase IV is required for fear memory.  Nature Neuroscience, 5:573-579 (Comment in: The Lancet 360:426, 2002).



53.      Kerchner, GA and Zhuo, M. (2002).  resynaptic suppression of dorsal horn inhibitory transmission by -opioid receptors.  J Neurophysiology, 88:520-522.



54.      Kim, S.J., Wei, F. and Zhuo, M (2002).  Inhibition of spinal nociception by activation of metabotropic glutamergic receptors in the rostroventral medulla in rats.  harmacol Biochem Behavior 73:429-437 (Special issue on metabotropic glutamate receptors, invited and peer-reviewed).



55.      Robinson, D.A., Calejesan, A.A. and Zhuo, M (2002).  Long-lasting changes in rostral ventral medulla neuronal activity following inflammation in the adult rat.  Journal of Pain, 3:292-300.



56.      Kerchner, G.A., Wilding, T.J., Huettner, J.E. and Zhuo, M (2002).  Kainate receptor subunits underlying presynaptic regulation of transmission release in the dorsal horn. J Neuroscience 2002 22:8010-7.    



57.      Wei, F., Qiu, C.S., Kim, s.j., Muglia, L., Maas, J.W., Pineda, V.V., Xu, H.-M., Chen, Z.-F., Storm, D.R., Muglia, L.J. Zhuo M. (2002).  Genetic elimination of synaptic potentiation and behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases.  Neuron, 36:713-726 (Neuron Press Release; November 14).



58.      Zhuo, M. and Gebhart G.F (2002).  Modulation of noxious and non-noxious spinal mechanical transmission from the rostroventral medial medulla in the rat.  J Neurophysiology,88:2928-2941.



59.      Wang H, Shimizu E, Tang YP, Cho M, Kyin M, Zuo W, Robinson DA, Alaimo PJ, Zhang C, Morimoto H, Zhuo M, Feng R, Shokat KM, Tsien JZ (2003). Inducible protein knockout reveals temporal requirement of CaMKII reactivation for memory consolidation in the brain.  roc Natl Acad Sci USA 100:4287-92.



60.      Liauw, J., Wang, G.-D. and Zhuo, M. (2003).  NMDA receptors contribute to synaptic transmission in anterior cingulate cortex of adult mice.  Acta Physiologica Sinica, 55:373-380.



61.      Tao, Y.-X., Rumbaugh, G, Wang, G.D., Petralia, R.S., Zhao, C., Kauer, F.W., Tao, F., Zhuo, M., Wenthold, R.J., Raja, S.N., Huganir, R.L., Bredt, D.S., Johns R.A. (2003).  Impaired NMDA receptor-mediated postsynaptic function and associated pain in PSD-93 knockout mice.  J Neuroscience 23:6703-6712.



62.      Wei, F. Xia-Ming Xia, Jianrong Tang, Shana Ko, Jason Liauw, Chang-Shen Qiu and Min Zhuo (2003).  Regional targeted gene transfer in anterior cingulate cortex of adult mice. J Neurosci. in press.



Reviews and book chapters

63.      Zhuo M, Gebhart GF (1993).  Central pain modulation:  Descending facilitatory system. Progress in Physiological Science 24:252-254.



64.      Hawkins RD, Zhuo M, Arancio A (1994).  Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation.  In: Takahi H, Toda N, Hawkins RD (Eds.) Nitric oxide: roles in neuronal communication and neurotoxicity.  CRC Press, Boca Raton; PP.129-147.  



65.      Hawkins RD, Zhuo M, Arancio A (1994).  Nitric oxide and carbon monoxide as possible retrograde messengers in hippocampal long-term potentiation. J. Neurobiology, 25:652-665.



66.      Zhuo M, Hawkins RD (1995).  Long-term depression:  a learning-related type of synaptic plasticity in the mammalian central nervous system. Reviews in Neurosciences, 6:259-277.



67.      McKnight GS, Idzerda RL, Kandel ER, Brandon EP, Zhuo M, Qi M, Bourtchouladze R, Huang Y, Burton KA, Skålhegg BS, Cummings DE, Varshavshy L, Planas JV, Motamed K, Gerhold KA, Amieux PS, Guthrie CR, Millett KM, Belyamani M and Su T (1996).  Targeted disruption of the protein kinase A system in mice. In: Signal transduction in testicular cells Ed. Hansson, V., Levy, F.V. and Tasken, K. Springer-Verlag, PP. 95-122.



68.      Zhuo M (1997).  A diffusible neuronal messenger in the brain:  nitric oxide.  In:  Fudan lectures in Neurobiology, 1997; 13:41-50.  



69.      Kerchner, G.A., Li, P. and Zhuo, M (1999).  Speaking out of turn: a role of silent synapses in pain.  Life, 1999, 48:251-256.



70.      Bito, H., Kavalali, E.T., Zhuo, M. Deisseroth, K. amd Tsien, TW (1999).  Synaptic modulation of dendritic Ca2+ influx and gene expression.  In: Slow synaptic responses and modulation, Eds K.Kuba, Higasshida, H., Brown, D.A. and Yoshioka, T., Springer-Verlag Tokyo, 1999, PP182-187.



71.      Zhuo, M (2000).  Silent glutamatergic synapses and long-term facilitation in spinal dorsal horn neurons.  rogress in Brain Research, 129:101-113.



72.      Ren, K., Zhuo, M. and Willis, WD (2000).  Multiplicity and plasticity of descending modulation of nociception: implications of persistent pain.  In Proceedings of the 9th World Congress on Pain, Progress in Pain research and management.  Vol. 16, edited by M. Devor, M.C. Rowbotham and Z. Wiesenfield-Hallin, IPSP Press, Seattle, 2000, page 387-400.



73.      Zhuo, M (2001).  No pain, no gains.  TheScientificWorld,  http://www.TheScientificWorld.com, 1:204-206.



74.      Zhuo, M (2002).  Glutamate receptors and persistent pain: targeting forebrain NR2B subunits.

Drug Discov Today. 7:259-267.



75.      Huettner, J.E., Kerchner, G.A. and Zhuo, M (2002).  Glutamate and presynaptic control of spinal sensory transmission.  Neuroscientist. 8:89-92.



76.      Robinson D. and Zhuo, M (2002).  Genetic analyses of pain mechanisms.  Crit Rev Eukaryot Gene Expr. 12:275-295.

77.      Robinson D. and Zhuo, M. (2002).  harmacological interventions at the spinal cord: intrathecal injections.   Methods in Molecular Biology/Biotechnology/Medicine, Humana Press.



78.      Robinson D. and Zhuo M (2002).  Glutamatergic synapses as potential targets for controlling persistent pain.  Current Anaesthesia and Critical Care, in press.



79.      Zhuo M (2003).  Synaptic and molecular mechanisms for pain and memory.  Acta Physiologica Sinica, 55:1-8.



80.      Zhuo, M (2003).  Transworld Research Network.  Recent research developments in cell biology.



81.      Zhuo, M (2004).  Central plasticity in pathological pain.  The Novaris Foundation symposium, Pathological pain: from molecular to clinical aspects.



82.      Robinson D. and Zhuo M (2004).  Endogenous facilitatory system: a novel pain modulatory mechanism.  Current Neurovascular Research.





Early articles for general readers



83.      Zhuo, M (1984).  Computer: Future king of Chess.  Spring of Science 6:9-11, 1984 (in Chinese).



84.      Zhuo, M (1983).  Recent study of left-handed person.  Spring of Science 5:3-5, 1983 (in Chinese).



85.      Zhuo, M (1982). Asexual reproduction of Human.  Young People of Fujian 8:56-58, 1982 (in Chinese).





Submitted studies



86.      Shanelle Ko, Daphné A Robinson, Hushan Ao, Micheal Rowley, Lorena Villaseñor, Talal Chatila and Min Zhuo (2003).  CaMKIV is required for emotional vocalizations related to dangerous stimuli.  J Neurosci.  



87.      Zerbinatti et al (2003).  Increased soluble A is associated with memory deficits in aged PDAPP/LRP double transgenic mice. Science.



88.      Daphné A. Robinson and Min Zhuo (2003).  Optical monitoring of the modulation of presynaptic activity in cultured dorsal horn neurons.  J Physiology.



Abstracts



89.      Zhuo, M. (1999). Descending inhibition and facilitation of nociception.  International Association for the study of Pain, 9th World Congress on Pain, Vienna, Austria.
 

90.      Kerchner, G.A., Wilding, T.J., Li, P., Zhuo, M and Huettner, JE  (2000).  RESYNAPTIC KAINATE RECEPTORS REGULATE SPINAL SENSORY TRANSMISSION. 2000 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. Online.



91.      Feng, J., Yan, Z., Ferreira, A., Tomizawa, K., Liauw, J.A., Zhuo, M., Allen, P.B., Ouimet, C.C. and Greengard, P (2000).  REGULATION BY SPINOPHILIN OF THE FORMATION AND FUNCTION OF DENDRITIC SPINES.  2000 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. Online.



92.      Wang, G.-D., Li, P. and Zhuo, M. (2000).  NMDA RECEPTOR-MEDIATED SENSORY SYNAPTIC RESPONSES IN ADULT MOUSE SPINAL CORD.  2000 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. Online.



93.      Wei, F. and Zhuo, M. (2000).  OTENTIATION OF SYNAPTIC RESPONSES IN THE ANTERIOR CINGULATE CORTEX FOLLOWING DIGITAL AMPUTATION IN RAT.  2000 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. Online.



94.      Robinson, D.A., Calejesan, A.A. and Zhuo, M  (2000).  RAPID ALTERATION OF ROSTROVENTRAL MEDULLA NEURONAL ACTIVITY FOLLOWING TISSUE INJURY AND INFLAMMATION.  2000 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. Online.



95.      Zhuo, M. et al (2000).  ROLE OF EGR1 IN HIPPOCAMPAL SYNAPTIC ENHANCEMENT INDUCED BY TETANIC STIMULATION AND AMPUTATION.  2000 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2000. Online.



96.      Robinson DA, Wei F, Wang GD, Li P,  Kim SJ, Vogt SK, Muglia LJ, Zhuo M  (2001). OXYTOCIN INHIBITS GLUTAMATERGIC SPINAL SENSORY TRANSMISSION AND MEDIATES STRESS-INDUCED ANTINOCICEPTION. 2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. Online.



97.      Li, P. and Zhuio, M. (2001).  SYNAPTIC MECHANISMS FOR ASPIRIN- AND DAMGO-PRODUCED ANALGESIA IN MAMMALIAN SPINAL DORSAL HORN. 2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. Online.



98.      Qiu, C.S. and Zhuo, M. (2001).  EFFECTS OF MORPHINE ON THE EXPRESSION OF CONDITIONED FEAR AND INFLAMMATORY PAIN IN MICE. 2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. Online.



99.      Wang, G.-D. and Zhuo, M. (2001).  FOREBRAIN NMDA RECEPTORS CONTRIBUTE TO NEURONAL ACTION POTENTIALS IN ADULT MICE. 2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. Online.



100.      Wei, F., Qiu, C.S., Kim, s.j., Muglia, L., Maas, J.W., Pineda, V.V., Xu, H.-M., Chen, Z.-F., Storm, D.R., Muglia, L.J. Zhuo M. (2001).  REDUCED INFLAMMATORY PAIN AND PRESERVED ACUTE PAIN IN MICE LACKING CALMODULIN STIMULATED ADENYLYL CYCLASES.  2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. Online.



101.      Kerchner, G.A., Huettner, JE and Zhuo, M. (2001).  RESYNAPTIC KAINATE RECEPTORS AT DORSAL HORN INHIBITORY SYNAPSES: MECHANISM OF ACTION.  2001 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2001. Online.



102.      C.-S. Qiu, F. Wei, J. Liauw, D.A. Robinson, N. Ho, T. Chatila, J. Millbrandt, M. Zhuo (2002). DISTINCT SIGNALING MOLECULES FOR FEAR MEMORY AND PERSISTENT PAIN Program No. 283.3. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.



103.      F. Wei, X.-M. Xia, C.-S. Qiu, S. Ko, M. Zhuo. REGIONALLY TARGETED GENE TRANSFER IN ADULT MAMMALIAN BRAIN BY IN VIVO ELECTROPORATION (2002). Program No. 283.7. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.



104.      Y.-X. Tao, G. Rumbaugh, G.-D. Wang, C. Zhao, F. Kauer, M. Zhuo, S.N. Raja, R.L. Huganir, D.S. Bredt, R.A. Johns. (2002).  IMPAIRED PERSISTENT PAIN AND NMDA RECEPTOR FUNCTION IN MICE LACKING PSD-93 Program No. 655.1. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.



105.      R. Darbandi-Tonkabon, R. Hastings, X. Chun-Min, D.F. Covey, M. Zhuo, A.S. Evers. (2002).  HOTOAFFINITY LABELING OF A NEUROACTIVE STEROID BINDING PROTEIN IN RAT BRAIN MEMBRANES Program No. 739.8. 2002 Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience, 2002. Online.



106.      Zhuo, M. (2002).  Forebrain NMDA NR2B receptors in chronic pain.  International Symposium on Plasticity of Pain System (ISPPS).  Fukuoka, Japan.



107.      Zhuo, M. (2002).  Kainate receptor in pain transmission and modulation.  Jacques Monod Conference: Glutamate receptors and transporters.  Anglet, France.



108.      Zhuo M. (2003).  Glutamate subtype receptors: from sensory transmission and modulation to chronic pain.  British Neuroscience Association the 17th meeting, Harrogate, 2003, UK.



109.      Zhuo, M. (2003).  Is cortical plasticity relevant to chronic pain?  American Pain Society 22th Annual meeting, Chicago, USA.



110.      J. Tang; C.S. Qiu; M. Zhuo (2003).  FEARFUL MEMORY INDUCED BY PAIRING A TONE WITH FOCAL STIMULATION OF ANTERIOR CINGULATE CORTEX IN FREELY MOVING MICE.  Society for Neuroscience.



111.      Robinson DA and Zhuo, M (2003).  Optical monitoring of the modulation of presynaptic activity in cultured dorsal horn neurons.  Society for Neuroscience.



112.      Ko, S., Robinson, DA, Rowley, M., Villasenor, L., Chatila, T., Zhuo, M. (2003).  Emotional vocalizations are altered in CaMKIV knockout mice.  Society for Neuroscience.





US and international patents



113.      U.S. Class    422/103, Patent Number 6096302, Issue Date    2000 08 01

     Assignee      The Trustees of Columbia University in the City of New York

     Inventor(s)   Kandel, Eric R., Bach, Mary E., Zhuo, Min

     Title: Assay for the measurement of neuronal degradation and uses
               Thereof



114.      ending

Assignee   Washington university and Princeton University

Inventor(s)  Min Zhuo and Joe Tsien

Title:  METHODS FOR MODULATING PERSISTENT PAIN AND FOR IDENTIFYING AGENTS TO TREAT PERSISTENT PAIN.



115.      ending

Assignee   Washington University and University of Washington

Inventor(s)  Min Zhuo, Louis J Muglia, and Daniel R. Storm

Title:  METHODS FOR control allodynia and persistent pain and for identifying agents to treat

persistent pain.  





Previous mentors and potential referees

Dr. G.F. Gebhart (Ph.,D. thesis mentor), Chairman, Department of Pharmacology, University of Iowa, E-mail: gfgebhar@blue.weeg.uiowa.edu

Dr. Eric R. Kandel (Post-doc mentor), University Professor, HHMI senior investigator, Center for Neurobiology and Behavior, Columbia University, E-mail: erk5@columbia.edu.  

Dr. Richard W. Tsien (Post-doc mentor), Gregory D. Smith Professor, Molecular and Cellular Physiology Department, Stanford University, rwtsien@leland.stanford.edu <rwtsien@leland.stanford.edu>

Dr. Paul Greengard, Vincent Astor Professor, Rockefeller University, greengd@rockvax.rockefeller.edu <greengd@rockvax.rockefeller.edu>,

Dr. Thomas Sudhof, Director, Center for Basic Neurosciences, University of Texas at Dallas, E-mail: Thomas.Sudhof@UTSouthwestern.edu.



News coverage of scientific findings from Zhuo’s lab



116.      The Scientist_The Notebook,

PAIN EXPLAINED: Washington University’s Min Zhuo found that a region of the brain in rats could activate neurons in the spinal cord, possibly causing feelings ...

www.the-scientist.com/yr1998/july/notebook_980706.html.



117.      Normally Silent Synapses in Spinal Cord Become Active to Produce Chronic Pain, National Institute on Drug Abuse, Director’s Report to the National Advisory Council on Drug Abuse; February, 1999.



118.      Mice and Memory,

The genes we share, A report from HHMI,



119.      Can Smart Be Painful?

At least in mice, the two seem somehow linked; http://www.healingwell.com/



120.      Scientists Create Smart Mouse

Addition Of Single Gene Improves Learning And Memory; 1999-09-02, Science Daily.



121.      Killing chronic pain in the brain,

13 November 2002 16:00 EST, BioMedNet  Top Stories.



122.      No pain, no brains?
 www.academicpress.com/inscight/01292001.  



123.      Study Links Chronic Pain to Signals in the Brain

Tuesday, January 07, 2003, NIH-NINDS News Articles.