[转贴]线粒体的一个小热休克蛋白HSP22的表达与寿命的关系

J Biol Chem. 2004 Aug 25 [Epub ahead of print] Related Articles, Links


Decreased lifespan in absence of expression of the mitochondrial small heat shock protein Hsp22 in Drosophila.

Morrow G, Battistini S, Zhang P, Tanguay RM.

Medicine Dept., Universite Laval, Ste-Foy, Quebec G1K 7P4.

Aging is a well-regulated biological process involving oxidative stress and macromolecular damages. Three main pathways have been shown to influence lifespan, the insulin/IGF-1 pathway, the silent regulator (SIR) pathway and the target of rapamycin (TOR) pathway. Among many proteins influencing lifespan, two transcription factors, FOXO and the heat shock factor (HSF), have been shown to be involved in the aging process and in small heat shock proteins (sHsps) expression following stress and during lifespan. We have recently shown that over expressing the mitochondrial Hsp22 increases Drosophila melanogaster lifespan by 32% and resistance to oxidative stress. Here we show that flies which are not expressing this mitochondrial small Hsp22 have a 40% decrease in lifespan. These flies die faster than their matched control and display a decrease of 30% in locomotor activity compared to controls. The absence of Hsp22 also sensitizes flies to mild stress. These data support a key role of sHsps in aging and underline the importance of mitochondrial sHsps in this process.

PMID: 15331597 [PubMed - as supplied by publisher]