Prefrontal and amygdala volumes are related to adolescents' affective behaviors during parent–adolescent interactions
Sarah Whittle*,,, Marie B. H. Yap*,, Murat Yücel*,, Alex Fornito,,, Julian G. Simmons*,, Anna Barrett*,,, Lisa Sheeber, and Nicholas B. Allen*,,¶
*ORYGEN Research Centre, Melbourne Neuropsychiatry Centre, Department of Psychiatry, and Department of Psychology, University of Melbourne, Parkville 3052, Victoria, Australia; and Oregon Research Institute, Eugene, OR 97403 Edited by Michael I. Posner, University of Oregon, Eugene, OR, and approved December 31, 2007 (received for review October 16, 2007) Abstract
Adolescence is a key period for the development of brain circuits
underlying affective and behavioral regulation. It remains unclear,
however, whether and how adolescent brain structure influences
day-to-day affective behavior. Because of significant changes
in the nature of family relations that also typically occur
during adolescence, parent–child interactions provide
a meaningful context where affective behavior and its regulation
may be assessed. In a sample of 137 early adolescents, we investigated
the relationship between aspects of the adolescents' brain structure
and their affective behavior as assessed during observation
of parent–child interactions. We found a significant positive
association between volume of the amygdala and the duration
of adolescent aggressive behavior during these interactions.
We also found male-specific associations between the volume
of prefrontal structures and affective behavior, with decreased
leftward anterior paralimbic cortex volume asymmetry associated
with increased duration of aggressive behavior, and decreased
leftward orbitofrontal cortex volume asymmetry associated with
increased reciprocity of dysphoric behavior. These findings
suggest that adolescent brain structure is associated with affective
behavior and its regulation in the context of family interactions,
and that there may be gender differences in the neural mechanisms
underlying affective and behavioral regulation during early
adolescence. Particularly as adolescence marks a period of rapid
brain maturation, our findings have implications for mental
health outcomes that may be revealed later along the developmental
trajectory.
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