[原创] 神经元-神经元之间LTP与神经元-NG2胶质细胞之间LTP的不同作用

就是两个脉冲的尖峰不是同时发生的情况，有先后

我觉得这样才比较合理

结果搞出来一个模型

模型的规则导致自然条件下会形成环路

如果不是这样的话我得再想想

 

[em06]

QUOTE:

以下是引用thinker_jeff在2006-6-13 20:33:00的发言：

Well, I can use my home computer in Chinese, but still have to use English for the computer in my office.

Sometimes it's hardly to say which is easy to me, because my typing skill is poorer in Chinese but my language ability is poorer in English too.

 [em04]

How about you explain more for your opinion - 编码好象一般从spike的角度来思考?

hardly->hard

easy->easier

poorer->poor (which are you comparing with?)

QUOTE:

以下是引用汪之旻在2006-6-13 20:53:00的发言：

hardly->hard

  Good catch.

easy->easier

  Good catch.

poorer->poor (which are you comparing with?)

  Typing in Chinese is poorer than in English. The language ability is reversed to the other way. 

诱导LTP时用的PAIRED INDUCTION就是类似你说的那样，有一个TIME WINDOW，突触前给的PULSE如果在突触后产生PULSE前５s左右，就能诱导LTP，反之，如果在后，则诱导出LTD。这是老蒲最有名的TIME WINDOW现象。当时这篇文章由BI GUOQING发表在JNS上后，引用率已快４００。

Synaptic Modifications in Cultured Hippocampal Neurons: Dependence on Spike Timing, Synaptic … - 所有 11 个版本»
G Bi, M Poo - Journal of Neuroscience, 1998 - jneurosci.org
In cultures of dissociated rat hippocampal neurons, persistent potentiation and depression of glutamatergic synapses
were induced by correlated spiking of presynaptic and postsynaptic neurons. The relative timing between the presynaptic
and postsynaptic spiking determined the direction and ...
被引用次数：380 - 网页搜索

QUOTE:

以下是引用bioguider在2006-6-13 21:21:00的发言：

诱导LTP时用的PAIRED INDUCTION就是类似你说的那样，有一个TIME WINDOW，突触前给的PULSE如果在突触后产生PULSE前５s左右，就能诱导LTP，反之，如果在后，则诱导出LTD。

"5 s" or "5 ms"? The paper seems saying there is a 20 msec window.

看来，我还是猜对了一半，自己鼓励一下。

有点逻辑的味道，好像还给出了不少参数，不过这个衰减函数还是不能确定……

还有个LTD没有概念，需要加进去……

难道真的有LTD？

一般的连接不会衰减吗？

[em06]

QUOTE:

以下是引用thinker_jeff在2006-6-13 22:30:00的发言：

"5 s" or "5 ms"? The paper seems saying there is a 20 msec window.

The same question that I want to ask.

In my imagination, The enviroment of lab will affect the response of the neuron cells.

He only talks about “within” but what will happen if they spike at the same time?

http://www.jneurosci.org/cgi/content/abstract/26/16/4178?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&fulltext=LTP+LTD+time&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&resourcetype=HWCIT