神经所新课题组导师Zhi-Qi (Jason) Xiong

CURRICULUM VITAE



Zhi-Qi (Jason) Xiong,  h.D.



BIRTHPLACE      Hunan Province, P. R. China

     

BIRTHDATE      August 19, 1968

     

MARITAL STATUS

     Married to Chi Zhang

Child: Andy Xiong     Born: November 2, 1996
           Jeff  Xiong       Born: January 13, 2003

     

ADDRESS      Duke University Medical Center

Box 3676

401 Bryan Research Building for Neurobiology

Research Drive

Durham, NC 27710

     

EMAIL      xiong@neuro.duke.edu  

xiongzq@yahoo.com



     

TELEPHONE      919-684-4241 (lab);    919-490-5883 (home)





EDUCATION & TRAINING



Postdoctoral training
 March, 2000-Present      Duke University Medical Center

Department of Neurobiology

Projects: “Complement, seizure, and neurodegeneration”
                 “BDNF-TrkB signaling in epileptogenesis”

       

Ph.D.  

August, 1995-Feb., 2000                               Baylor College of Medicine

Department of Pharmacology and Division of  Neuroscience

Dissertation: “Ionic Mechanisms of Epileptiform Activity”

     

M.S.

Sept., 1992-July, 1995      Shanghai Institute of Materia Medica

Chinese Academy of Sciences

Department of Pharmacology

Thesis:  “Effects of Huperzine A and its Analogs on     
                Cholinesterases and Memory Impairments”

     

Pharm.B.

Sept., 1987-June, 1992      West China University of Medical Sciences

(Sichuan University Huaxi Medical Center)

School of Pharmacy

Thesis:  “Pharmacological and toxicological studies of
                Chinese traditional herb—Yangjianhua”



WORKING EXPERIENCE





Research Associate      Duke University Medical Center

     

March, 2000-Present      Department of Neurobiology  

Dr. James O. McNamara’s lab

Calcium imaging; Confocal microscopy

Primary cortical and hippocampal cultures

Hippocampal explant cultures

In vivo EEG recordings

Multi-electrode array recordings

Whole-cell patch recordings

Biochemical and molecular techniques

     

     

Research Assistant      Baylor College of Medicine

     

Dec., 1998-Sept., 1999      Division of Neuroscience

Dr. Peter Saggau’s lab

Optical recording techniques

     

April, 1998-June, 1998      Division of Neuroscience

Dr. John Dani’s lab

Neuronal microisland cultures

Whole cell patch recordings

     

August, 1995-Feb., 2000      Department of Pharmacology and Division of neuroscience

Dr. Janet L. Stringer’s lab

In vivo electrophysiological recordings

In vitro intracellular and extracellular recordings

Ion-sensitive microelectrodes (pH, K+, Ca2+)

Immunohistochemistry

     

     

Research Assistant      Shanghai Institute of Materia Medica

Chinese Academy of Sciences

     

Sept., 1992-June, 1995      Department of Neuropharmacology

Professor Xi-Can Tang’s lab

Drug screening; Neurochemistry

Behavioral pharmacology

(rat spatial learning and memory)

     


 

PUBLICATIONS


                                

1.      Xiong Z-Q and McNamara JO.   Blockade of complement-induced neuronal cell death by low molecular organic inhibitors of membrane attack complex.  In preparation.



2.      Xiong Z-Q, Qian W, Suzuki K, and McNamara JO.  (2003).  Formation of complement membrane attack complex in mammalian cerebral cortex evokes seizures and neurodegeneration.  J. Neurosci. 23: 955-960.



3.      Xiong Z-Q and McNamara JO.  (2002).  Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack.  Neuron 36: 363-374.



4.      Xiong Z-Q and McNamara JO.  (2002).  Fas(t) balls and Lou Gehrig disease: a clue to selective vulnerability of motor neurons? Neuron 35: 1011-1013. (preview)



5.      Xiong Z-Q and Stringer JL.  (2001). Prolonged bursts occur in normal calcium levels in hippocampal slices after raising excitability and blocking synaptic transmission. J. Neurophysiol. 86: 2625-2628.



6.      Xiong Z-Q and Stringer JL.  (2001).  Effects of postsynaptic GABAB receptor activation on epileptiform activity in hippocampal slices. Neuropharmacology 40: 131-138.



7.      Xiong Z-Q, Saggau P, and Stringer JL.  (2000).  Activity-dependent intracellular acidification correlates with the duration of seizure activity.  J. Neurosci. 20: 1290-1296.



8.      Xiong Z-Q and Stringer JL.  (2000).  Extracellular pH responses in CA1 and the dentate gyrus during electrical stimulation, seizure discharges, and spreading depression.  J. Neurophysiol. 83: 3519-3524.



9.      Schweitzer JS, Wang H, Xiong Z-Q, and Stringer JL.  (2000).  pH sensitivity of non-synaptic field bursts in the dentate gyrus. J. Neurophysiol. 84: 927-933.



10.      Xiong Z-Q and Stringer JL.  (2000).  Sodium pump activity, not glial spatial buffering, clears potassium after epileptiform activity induced in the dentate gyrus.  J. Neurophysiol. 83: 1443-1451.



11.      Xiong Z-Q and Stringer JL.  (2000).  Regulation of extracellular pH in the developing hippocampus.  Dev. Brain Res. 122: 113-117.



12.      Xiong Z-Q and Stringer JL.  (1999).  Astrocytic regulation of the recovery of extracellular potassium after seizures in vivo.  Eur. J. Neurosci. 11: 1677-1684.



13.      Xiong Z-Q and Stringer JL.  (1999).  Cesium induces spontaneous epileptiform activity without changing extracellular potassium regulation in rat hippocampus.  J. Neurophysiol. 82: 3339-3346.



14.      Xiong Z-Q, Cheng DH, and Tang XC.  (1998).  Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit.  Acta Pharmacologica Sinica 19: 128-132.



15.      Xiong Z-Q and Stringer JL.  (1997).  Effects of felbamate, gabapentin and lamotrigine on seizure parameters and excitability in the rat hippocampus. Epilepsy Res. 27: 187-194.



16.      Xiong Z-Q, Han YF, and Tang XC.  (1995).  Huperzine A ameliorates the spatial working memory impairments induced by AF64A.  NeuroReport  6: 2221-2224.



17.      Xiong Z-Q and Tang XC.  (1995).  Effect of huperzine A, a novel acetyl-cholinesterase inhibitor, on radial maze performance in rats.  harmacol. Biochem. Behav. 51: 415-419.



18.      Xiong Z-Q and Tang XC.  (1995).  Effects of isovanihuperzine A on cholinesterase and scopolamine-induced memory impairment.  Acta Pharmacologica Sinica 16: 21-25.



19.      Xiong Z-Q and Tang XC.  (1995).  Effect of N-nitro-L -arginine on eight-arm maze performance in rats.  Acta Pharmacologica Sinica 16: 301-304.



20.      Tang XC, Xiong Z-Q, Qian BC, Zhou ZF.  (1994).  Cognition improvement by oral huperzine A: a novel acetylcholinesterase inhibitor. In Giacobini E and Becker R Eds. Alzheimer Therapy: Therapeutic Strategies. Birkhauser, Boston. 113-119 (review)







MEETING ABSTRACTS AND PRESENTATIONS:





1.      Xiong Z-Q and McNamara JO.  2002.  Fleeting activation of ionotropic glutamate receptors sensitizes cortical neurons to complement attack.  

Poster presentation:  the 32th Annual Meeting of Society for Neuroscience.  Orlando, FL.



2.      Stringer JL and Xiong Z-Q.   2000.  In hippocampal slices, blocking synaptic transmission allows the appearance of field bursts in normal extracellular calcium levels.  

Poster presentation:   the annual Meeting of the American Epilepsy Meeting. Los Angeles, CA.  

Abstract:   Epilepsia  41(suppl. 7): 5.  



3.      Xiong Z-Q and Stringer JL.  2000. Activity-dependent intracellular acidification correlates with the duration of seizure activity.

Abstract:   BCM  Graduate Student Symposium 2000: 230.



4.      Xiong Z-Q and Stringer JL  1999.  Sodium pump activity, not glial spatial buffering, accounts for  the potassium clearing during and after epileptiform activity induced in the dentate gyrus.  

Poster presentation:  Graduate Student Symposium, Baylor College of Medicine.  Houston, TX.    Abstract 1999: 244.

Poster presentation:  the Ninth Annual Rush & Helen Record Neuroscience Forum.  Galveston, TX. Abstract:  p53.

Poster presentation:  the 29th Annual Meeting of Society for Neuroscience.  Miami Beach, FL.

Soc Neurosci Abstr:  25: 843.



5.      Xiong Z-Q and Stringer JL.  1998.  The contribution of gap junctions to nonsynaptic epileptiform activity in rat dentate gyrus.  

Poster presentation:   the eighth Annual Rush & Helen Record Neuroscience Forum.  Galveston, TX. Abstract: p44.

Poster presentation:  the Graduate Student Symposium, Baylor College of  Medicine.  Houston, TX. Abstract 1998: p250.

Poster presentation:  the 28th Annual Meeting of Society for Neuroscience.  Los Angles, CA.

Soc Neurosci Abstr:   24: 1214.



6.      Xiong Z-Q and Stringer JL.  1997.  Role of glia in regulation of extracellular potassium during seizures.

Poster presentation:  the Graduate Student Symposium, Baylor College of Medicine.  Houston, TX.  Abstract 1997: 228.

Poster presentation:  the 27th Annual Meeting of Society for Neuroscience.  New Orleans, LA.

Soc Neurosci Abstr:  23: 2264.



7.      Xiong Z-Q and Stringer JL.  1996.  Effects of felbamate and gabapentin on excitability in the dentate gyrus and on hippocampal seizures in vivo.

Poster presentation:  the 26th Annual Meeting of Society for Neuroscience.  Washington, D.C.

Soc Neurosci Abstr:  22: 2105.



8.      Yeung OY, Xiong Z-Q, Tang XC, and Han YF.  1995. Comparison of memory-enhancing effects of huperzine A and tacrine on the radial maze performance of scoplamine-treated rats.

Poster presentation:  the 25th Annual Meeting of Society for Neuroscience.  San Diego, LA.

Soc Neurosci Abstr:  21: 165.







PATENTS



•      United States Patent, in process.  Low molecular weight organic inhibitors of complement membrane attack complex.  Inventors: James O. McNamara and Zhi-Qi Xiong.  Assignee: Duke University.







MEMBERSHIP IN PROFESSIONAL SOCIETIES



Society for Neuroscience

好象是灌水，没人看的。