Kang Shen

Name:                   Kang Shen



Address:                  Department of Anatomy,
                         University of California San Francisco
                        



Education:



Ph. D. 1994-99    Graduate student at the Department of Cell Biology
                 Duke University Medical Center



1995,7-1995,8     Physiology Summer Course at Marine Biological Laboratory
                  Woods Hole, Massachusetts



M. D. 1989-94     Medical Student at Tongji Medical University
                  Wuhan, Hubei, China



Research Experience:



1999-present       ostdoctoral Research Fellow
                   Laboratory of Dr. Cori Bargmann
                   HHMI, Dept of Anatomy, UCSF
                   San Francisco, CA
                   Molecular mechanisms of synapse formation in C. elegans



1994-99         Graduate Student
                   Laboratory of Dr. Tobias Meyer
                   Department of Cell Biology
                   Duke University
                   Durham, NC
                   Dynamic control of CaMKII localization in neurons



1991-92         Medical student
                   Laboratory of Dr. Ming Tang
                   Department of Physiology
                   Tongji Medical University
                   Wuhan, China
                   Effects of Tetrandrine on L-type Ca2+ channel in cardiac myocytes



Fellowships and Awards:



2000-present            Helen Hay Whitney Postdoctoral Fellowship

1999                  Best thesis award, Dept of Cell Biology, Duke University

1994           Chancellor award-excellence in academic activities





Publications:



1.      Shen, K and Bargmann, CI  (2003) The Immunoglobulin Superfamily protein SYG-1 Determines the Location of Specific Synapses in C. elegans. Cell 112:619-630.

2.      Shen, K and Bargmann, CI  (2003) SYG-2, an Immunoglobulin Superfamily protein, defines synaptic specificity through interaction with SYG-1. Manuscript in preparation.

3.      Shen, K, Teruel MN, Connor JH, Shenolikar S, Meyer T. (2000)  Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nature Neuroscience 3:881-6

4.      Meyer T, Shen K. (2000) In and out of the postsynaptic region: signalling proteins on the move.  Trends Cell Biology 10:238-44.

5.      Raucher, D., Stauffer,T., Chen, W, Shen, K., York, J., Sheetz , M. and  Meyer, T. (2000) Cytoskeletal-plasma membrane adhesion energy regulated by phosphatidylinositol 4,5-bisphosphate. Cell 100:221-8.

6.      Shen, K and Meyer, T. (1999) NMDA-receptor controlled CaMKII translocation between F-actin, cytosol and PSD. Science 284:162-7

7.      Teruel, M.N., Blanpied, T. A., Shen, K., Augustin, G. J. and Meyer, T.  (1999) Quantitative, rapid and high-yield transfection of cultured hippocampla neurons by microporation of RNA. Journal of Neuroscience Methods 93:37-48.

8.      Shen, K., Teruel, M. N., Subramanian, K. and Meyer, T. (1998) CaMKIIb functions as and F-actin targeting module that localizes CaMKIIa/b hetero-oligomers to dendritic spines.  Neuron 21: 593-606.

9.      Shen, K., and Meyer, T. (1998). Identification of the Minimal Oligomerization Domain of Ca2+/Calmodulin Dependent Protein Kinase IIa. Journal of Neurochemistry. 70:96-104

10.      Bao,S., Shen, X, Shen, K., Liu, Y. and Wang, X. (1998) The Mammalian Rad42 Homologous to Yeast Saccharomyces cerevisiae Rad24 and Schizosaccharomyces pombe Rad17 Is Involved in G2 DNA Damage Checkpoint.  Cell Growth & Differentiation 9:961-7.



Conference Abstracts:



Oral Presentations:



2002    Shen, K and Bargmann, CI  SYG-1 and SYG-2, two Immunoglobulin Superfamily proteins, define synaptic specificity in C. elegans. Axon guidance and Neural plasticity, Cold Spring Harbor Meetings



2002    Shen, K and Bargmann, CI  SYG-1, an Immunoglobulin Superfamily protein, plays an essential role in synaptogenesis in C. elegans. West Coast Worm

meeting



2002    Shen, K and Bargmann, CI  SYG-1, an Immunoglobulin Superfamily protein, plays an essential role in synaptogenesis in C. elegans. Cell Biology of Neuron, Gordon Research Conference



2002    Shen, K and Bargmann, CI  Molecular mechanism of synaptogenesis in C. elegans.  atterning of the Brain, EMBO workshop, Ascona



2001    Shen, K and Bargmann, CI  Molecular mechanism of synaptogenesis in C. elegans.  13th International worm meeting



1999    Shen, K and Meyer, T. NMDA-receptor controlled CaMKII translocation between F-actin, cytosol and PSD.  Neural plasticity, Gordon Research Conference



1999    Shen, K., Teruel, M. N., Subramanian, K. and Meyer, T. (1999) CaMKIIb functions as and F-actin targeting module that localizes CaMKIIa/b hetero-oligomers to dendritic spines.  Axon guidance and Neural plasticity, Cold Spring Harbor Meetings



Poster Presentations:



2000    Shen, K, Teruel MN, Connor JH, Shenolikar S, Meyer T. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Neural plasticity, Keystone symposium



1998    Shen, K., Teruel, M. N., Subramanian, K. and Meyer, T. CaMKIIb functions as and F-actin targeting module that localizes CaMKIIa/b hetero-oligomers to dendritic spines. Neural plasticity, Keystone symposium