王路阳

简历

王路阳

1980.9.-1984.7.中国药科大学，学士

1984.9.-1987.11.中国药学院助教

1988.1-1989.8.多伦多大学药理学系，硕士，研究方向：心血管药理       

1989.9-1993.11.多伦多大学药理学系，博士，研究方向：神经药理        

1994.8-1998.22.耶鲁大学药理学系，研究方向：神经科学

1998-现在，加拿大多伦多病儿医院神经学部脑和行为研究组科学家，多伦多大学生理系助理教授

获奖情况：

1．      2002-2007：加拿大脑和行为“国家研究员交椅”研究教授职位奖

2．      2001-2004：美国Burroughs Wellcome Fund 新研究员奖

3．      2000-2003：加拿大EJLB基础研究奖

4．      1998：加拿大创新与机遇基金奖

5．      1998-2003： 加拿大CIHR新研究员奖学金

6．      1996-1997：美国耶鲁大学Eppley博士后奖学金

7．1996.4-5：英国国际人类前沿科学短期奖学金

8. 1995-1996:：美国耶鲁大学James Hudson Brown-Alexander B. Coxe 博士后奖

9. 1989: 加拿大埃德蒙顿临床研究优秀学生奖

10. 1988-1993: 加拿大多伦多大学特殊奖学金

11. 1988-1992: 加拿大多伦多大学Differential Fee Waiver 学生奖学金

12. 1989: 加拿大多伦多大学开放奖学金



Publications:

1.      Wang, L.-Y., Salter, M.W. and MacDonald, J.F. Regulation of kainate receptors by cAMP-dependent protein kinase and phosphatases. Science 253, 1132-1135 (1991).

2.      Wang, L.-Y., Taverna, F.A., Huang, X-P., MacDonald, J.F. and Hampson, D.R. Phosphorylation and modulation of a kainate receptor (GluR6) by  cAMP-dependent protein kinase. Science 259, 1173-1175 (1993).

3.       Wang, L.-Y., Dudek, E.M., Browning, M.D. and MacDonald, J.F. Modulation of AMPA/kainate receptors in cultured hippocampal neurons by protein kinase C. J. Physiol. (London) 475, 431-437 (1994)

4.       Wang, L.-Y., Orser, B.A., Brautigan, D.L. and MacDonald, J.F. Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A. Nature 369, 230-232 (1994).

5.      Taverna, F., Wang, L.-Y., MacDonald, J.F. and Hampson. D.R. A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides. J. Biol. Chem. 269, 14159-14164 (1994)

6.      Tymianski, M., Wang, L.-Y., and MacDonald, J.F. Alteration of neuronal calcium homeostasis and excitotoxic vulnerability by chronic depolarization. Brain Res. 648, 291-295 (1994)

7.      Orser, B.A., Wang, L.-Y., Pennefather, P.S. and MacDonald, J.F. Propofol (2,6 di-isopropyphenol) modulates GABAa receptors in hippocampal neurons. J. Neurosci. 14, 7747-7760 (1994)

8.      Taverna, F., Cameron, B.-R., Hampson, D.R., Wang, L.-Y. and MacDonald, J.F. Sensitivity of AMPA receptors to Pentobarbital. Euro. J. Pharmacol. (Mol. Pharmacol.)  267, R3-R5 (1994)

9.      Moss, S.M., Taverna, F., Pickering, D.S., Wang, L.-Y., MacDonald, J.F., Pennefather, P.S. and Hampson, D.R. Expression of functional metabotropic and ionotropic glutamate receptors in baculovirus-infected insect cells  Neurosci. Lett. 173, 139-142 (1994)

10.      Orser, B.A., Bertlik, M., Wang, L.-Y. and MacDonald, J.F. Propofol (2,6 di-isopropyphenol) selectively inhibits the N-methyl-D-aspartate subtype of glutamate receptor in cultured hippocampal neurones. Br. J. Pharmacol. 116, 1761-1768 (1995).

11.      Kanemasa, T., Gan, L., Perney, T.M, Wang, L.-Y. and Kaczmarek, L.K. Electrophysioloical and pharmacological characterization of a mammalian Shaw channel expressed in NIH 3T3 fibroblasts. J. Neurophysiol. 74, 207-217 (1995)  

12.      Wang, L.-Y. and MacDonald, J.F. Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurons. J. Physiol. (London) 486, 83-95 (1995).

13.      Hahn, S.J. Wang, L.-Y. and Kaczmarek, L.K. Inhibition by nystatin of Kv1.3 channels expressed in chinese hamster ovary cells.  Neuropharmacol. 35, 895-901 (1996)

14.      Joiner, W.J., Wang, L.-Y., Tang, M.D. and Kaczmarek, L.K. hSK4, a member of a novel subfamily of calcium activated potassium channels. Proc. Natl. Acad. Sci. USA 94, 11013-11018 (1997)

15.      Wang, L.-Y., Gan, L., Perney, T.M.,  Schwartz, I. And Kaczmarek, L.K. Activation of Kv3.1 Channels in Neuronal Spine Like Structures may Induce Local Potassium Ion Depletion. Proc. Natl. Acad. Sci. USA 95, 1882-1887 (1998).

16.      Wang, L.-Y., Gan, L., Forsythe, I.D. and Kaczmarek, L.K. Contribution of the Kv3.1 Potassium Channel to High Frequency Firing in Mouse Auditory Neurones. J. Physiol. (London) 509, 183-194 (1998).

17.      Wang, L.-Y. and Kaczmarek, L.K. High Frequency firing helps replenish the readily releasable pool of synaptic vesicles. Nature 394, 384-388 (1998).

18.      Xiong, Z.G., Raouf, R., Lu, W.Y., Wang, L.-Y., Orser, B.A., Dudek, E.M., Browning, M.D., MacDonald, J.F. Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Mol. Pharmacol. 54,1055-1063 (1998)

19.      Joiner, W.J., Tang, M.D., Wang, L.-Y., Dworetzky, S.I., Boissard, C.G., Gan, L., Gribkoff, V.K. and Kaczmarek, L.K. Formation of intermediate conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neurosci. 1, 462-469 (1998).

20.      Smith, T.C., Wang, L.-Y. and Howe, J.R. Distinct kainate receptor phenotypes in immature and mature mouse cerebellar granule cells. J. Physiol. (London), 517, 51-58 (1999).

21.      Smith, T.C., Wang, L.-Y. and Howe, J.R. Heterogeneous conductance levels of native AMPA receptors. J. Neurosci. 20, 2073-2085 (2000).

22.      Wang, L.-Y. The Dynamic Range for Gain control of NMDA Receptor-Mediated Synaptic Transmission at a Single Synapse. J. Neuroscience 20 (RC115), 1-5 (2000).

23.      Joshi, I. and Wang, L.-Y., Developmental profiles of glutamate receptors and synaptic transmission at a single synapse in the mouse auditory  brainstem. J. Physiol. (Lond.). 540, 861-873(2002).

24.      Macica, C.M. von Hehn, C.A.A., Wang, L.-Y., Ho, C.-S., Yokoyama, S., Joho, R.H., and Kaczmarek, L.K. Modulation of the Kv3.1b Potassium Channel Isoform Adjusts the Fidelity of the Firing Pattern of Auditory Neurons.  J. Neurosci. 23, 1133-1141 (2003).



Reviews & Book Chapters

1.      MacDonald, J.F., Wang, L.-Y. and Salter, M.W. Phosphorylation of glutamate receptors using electrophysiology techniques. In: Ion Channels of excitable cells (T. Narahashi ed.) Methods In Neuroscience Vol. (19), p.304-319, Academic Press (1994).

2.      MacDonald, J.F., Bartlett, M.C., Orser, B.A., Fletcher, E.J., Browning, M.D. and Wang, L.-Y.. The reversible phosphorylation of glutamate receptors and long-term potentiation. In: Direct and allosteric control of glutamate receptors.  M.G. Palfreyman, I. Reynolds and P. Skolnick (ed.) Pharmacolgy & Toxicology: Basic and Clinical Aspects, p.77-93, CRC Press Inc. Boca Raton, FL (1994).

MacDonald, J.F., Browning, M.D. and Wang, L.-Y.. Long-term enhancement of excitability and the regulation of glutamate receptors by protein kinases In: Progressive nature of epileptogenesis. U. Heinemann, J. Engel Jr., G., G. Avanzini, B.S. Meldrum, A. Mouritzen-dam and C. Wasterlain (eds.) Epilepsy Research Suppl. 12, p. 275-282,  Elsevier Press (1996).