溶瘤病毒表达RANTES和细胞因子IL-15增强了CAR-T细胞在实体肿瘤中的功能

Oncolytic virus expressing RANTES and IL-15 enhances function of CAR-modified T cells in solid tumors

We improved the migration and survival of chimeric antigen receptor (CAR)-modified T cells in solid tumors by combining CAR-T cells with an armed oncolytic virus. Local delivery of the chemokine RANTES and the cytokine IL-15 by the oncolytic virus enhanced the trafficking and persistence of the CAR-T cells, resulting in improved antitumor effects.


KEYWORDS:
GD2 antigen; IL-15; RANTES; chimeric antigen receptor; oncolytic virus

溶瘤病毒表达RANTES和细胞因子IL-15增强了CAR-T细胞在实体肿瘤中的功能

我们通过结合一个加工的溶瘤病毒到CAR-T细胞，从而增加了CAR-T细胞在实体肿瘤中的转移能力和存活能力。通过溶瘤病毒局部递送趋化因子RANTES和细胞因子IL-15增强CAR-T细胞的能力和持久性，从而提高了抗肿瘤作用。

关键词：
GD2抗原，IL-5，RANTES，CAR，溶瘤病毒
出自爱康得生物技术