[转贴]神经再生与成体神经干细胞

目前，对于惊厥发作后出现在齿状回的具有神经元特征的新生细胞来源问题又有了新的观点。
2004年Hellsten J在Biol Psychiatry发表了一篇题为”Electroconvulsive seizures induce endothelial cell proliferation in adult rat hippocampus“的文章，他发现在电刺激诱导成年大鼠惊厥模型中发现BrdU标记的内皮细胞同神经前体细胞混杂出现在分子层、颗粒细胞层、SGZ和门区，而长时程的惊厥发作可以使血脑屏障受损，故海马结构中出现的新生神经元不排除来自外周细胞分化而来，这一发现不得不让我们换另一种思维来看问题。
摘要：
BACKGROUND: Electroconvulsive seizures, an animal model for electroconvulsive treatment, induce a strong increase in neurogenesis in the dentate gyrus of adult rats. Hippocampal neurogenesis has previously been described as occurring in an angiogenic niche. This study examines the effect of electroconvulsive seizures on proliferation of vascular cells in rat hippocampus. METHODS: Rats were injected with bromodeoxyuridine to label proliferating cells in the dentate gyrus after single/multiple electroconvulsive seizures in a dose-response study and at various time points after single electroconvulsive seizures in a time-course study. RESULTS: A dose-response effect on the number of bromodeoxyuridine-labeled endothelial cells located in the granule cell layer, hilus, and molecular layer was noted, as was the case with the number of neural precursors in the subgranular zone. The time-course study revealed that endothelial cell and neural precursor proliferation occurred in concert in response to a single electroconvulsive seizure. CONCLUSIONS: Our data suggest that in response to electroconvulsive seizures, endothelial cell and neural proliferation is coregulated. The increase in endothelial cell proliferation may act to support the increased neural proliferation and neuronal activity or vice versa, possibly leading to structural changes within the hippocampus of importance for the antidepressant effect of electroconvulsive seizures
pmid 14960296
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