王晓东教授要到生科院来做报告!

Institute of Neuroscience Research Seminar

Title: Biochemical Studies of Apoptosis.

Speaker: Xiao-Dong Wang Ph.D.
Investigator,
University of Texas Southwestern Medical Center at Dallas.

Time: 2004.3.1(Monday)
15:30 PM

Place: Lecture Hall of SIBS Building.

Welcome to attend!


Institute of Neuroscience
2004.2.26

王晓东简历

Personal Information:
Name: Xiaodong Wang, Ph.D.
Endowed Title: George L. MacGregor Distinguished Chair in Biomedical Science
Academic Title: Professor
Administrative Title: Professor
Primary Appointment: Biochemistry
University: Investigator, University of Texas Southwestern Medical Center at Dallas

Education:
B.S. Biology 1984 Beijing Normal University, Beijing, China
Ph.D. Biochemistry 1991 University of Texas Southwestern Medical Center, Dallas, Texas

Fellowships:
1991 - 1991 Damon Runyon-Walter Winchell Cancer Research Fund Postdoctoral Fellowship

Professional Associations / Affiliations:
American Association of Cancer Research
American Society of Biochemistry and Molecular Biology
American Society of Cell Biology
Ray Wu Society
Society of Chinese Biomedical Scientist in America

Honors and Awards:
2002 Hackerman Award The Welch Foundation
2001 Paul Marks Prize Memorial Sloan-Kettering Cancer Center
2000 Eli Lilly Award American Chemical Society
2000 Schering-Plough Award American Society of Biochemistry and Molecular Biology
1999 Young Investigator Award Society of Chinese Biomedical Scientist in America

Research Interests:
Xiaodong Wang studies the biochemical pathways that determine when and how cells die by apoptosis, using cultured human cells as a model system.


Publications:
1. Liu, Q., Rand, T. A., Kalidas, S., Du, F., Kim, H. E., Smith, D. P., and Wang, X. (2003). R2D2, a bridge between the initiation and effector steps of the Drosophila RNAi pathway. Science 301, 1921-1925. supplementary materials
2. Nijhawan, D., Fang, M., Traer, E., Zhong, Q., Gao, W., Du, F., and Wang, X. (2003). Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation. Genes Dev 17, 1475-1486.
3. Xuejun Jiang, Hyun-Eui Kim, Hongjun Shu, Yingming Zhao, Haichao Zhang, James Kofron, Jennifer Donnelly, Dave Burns, Shi-chung Ng, Saul Rosenberg, Xiaodong Wang (2003). Distinctive Roles of PHAP Proteins and Prothymosin-a in a Death Regulatory Pathway. Science 299 (5604): 223-226. Supplementary materials and comments.
4. Devrim Acehan, Xuejun Jiang, David Gene Morgan, John E. Heuser, Xiaodong Wang, and Christopher W. Akey (2002). Three-Dimensional Structure of the Apoptosome: Implications for Assembly, Procaspase-9 Binding, and Activation. Mol Cell 9(2): 423-432.
5. Xiaodong Wang (2001). The expanding role of mitochondria in apoptosis.Genes Dev 15(22):2922-33.
6. Piotr Widlak, Lily Y. Li, Xiaodong Wang, and William T. Garrard (2001). Action of recombinant human apoptotic endonuclease G on naked DNA and chromatin substrates: cooperation with exonuclease and DNase I. J Biol Chem 276 (51): 48404-9.
7. LILY Y. LI, XU LUO & XIAODONG WANG (2001). Endonuclease G is an apoptotic DNase when released from mitochondria. Nature 412(6842):95-9.
8. JAY PARRISH, LILY LI, KRISTINA KLOTZ, DUNCAN LEDWICH, XIAODONG WANG & DING XUE (2001). Mitochondrial endonuclease G is important for apoptosis in C. elegans. Nature 412(6842):90-4.
9. Xuejun Jiang and Xiaodong Wang (2000) Cytochrome c Promotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1. J Biol Chem 275(40): 31199-31203.
10. Michael Lutter, Min Fang, Xu Luo, Masahiro Nishijima, Xiao-song Xie and Xiaodong Wang (2000). Cardiolipin provides specificity for targeting of tBid to mitochondria. Nat Cell Biol 2(10):754-61.
11. Chunying Du, Min Fang, Yucheng Li, Lily Li, and Xiaodong Wang (2000). Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 102(1):33-42.
12. Deepak Nijhawan, Narimon Honarpour, and Xiaodong Wang (2000). Apoptosis in Neural Development and Disease. Annu. Rev. Neurosci. 23:73-87.
13. Piotr Widlak, Peng Li, Xiaodong Wang, and William T. Garrard (2000). Cleavage Preferences of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease) on Naked DNA and Chromatin Substrates. J Biol Chem 275(11): 8226-8232.
14. Geng Wu, Jijie Chai, Tomeka L. Suber, Jia-Wei Wu, Chunying Du, Xiaodong Wang & Yigong Shi (2000). Structural basis of IAP recognition by Smac/DIABLO. Nature 408 (6815):1008-12.
15. Jijie Chai, Chunying Du, Jia-Wei Wu, Saw Kyin, Xiaodong Wang & Yigong Shi. Structural and biochemical basis of apoptotic activation by Smac/DIABLO. Nature 406(6798):855-62.
16. Imawati Budihardjo, Holt Oliver, Michael Lutter, Xu Luo, and Xiaodong Wang (1999). BIOCHEMICAL PATHWAYS OF CASPASE ACTIVATION DURING APOPTOSIS. Annu. Rev. Cell Dev. Biol. 15:269-290.
17. Xuesong Liu, Hua Zou, Piotr Widlak, William Garrard, and Xiaodong Wang (1999). Activation of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease) OLIGOMERIZATION AND DIRECT INTERACTION WITH HISTONE H1. J Biol Chem 274(20): 13836-13840.
18. Hua Zou, Yuchen Li, Xuesong Liu, and Xiaodong Wang (1999). An APAF-1•Cytochrome c Multimeric Complex Is a Functional Apoptosome That Activates Procaspase-9. J Biol Chem 274(17): 11549-11556.
19. Xu Luo, Imawati Budihardjo, Hua Zou, Clive Slaughter, and Xiaodong Wang (1998). Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors. Cell, 94: 481-490.
20. Xuesong Liu, Peng Li, Widlak P, Hua Zou,Xu Luo,William T Garrard,Xiaodong Wang (1998) The 40-kDa subunit of DNA fragmentation factor induces DNA fragmentation and chromatin condensation during apoptosis. Proc Natl Acad Sci U S A 95(15):8461-6.
21. Peng Li, Deepak Nijhawan, Ima Budihardjo, S. M. Srinivasula, M. Ahmad, E. S. Alnemri & Xiaodong Wang (1997). Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell, 91: 479-489
22. Hua Zou,Willaim J. Henzel, Xuesong Liu, Alexis Lutschg, and Xiaodong Wang (1997). Apaf-1, a human protein homologous to C. elegans CED-4 participates in Cytochrome c-dependent activation of Caspase-3. Cell,90 (3):405-413.
23. Xuesong Liu, Hua Zou, Clive Slaughter, Xiaodong Wang (1997). DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis.Cell, 89 (2): 175-184.
24. Jie Yang, Liu Xuesong, Kapil Bhalla, Caryn Naekyung Kim, A.M. Ibrado, J. Cai, T.I. Peng, D.P. Jones, Xiaodong Wang (1997). Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked. Science 275(5303): 1129-1132.
25. Xuesong Liu, Caryn Naekyung Kim, Jan Pohl and Xiaodong Wang (1996). Purification and characterization of an interleukin-1b-converting enzyme family protease that activates cysteine protease P32 (CPP32). J.Biol. Chem. 271, 13371-13376.
26. Xuesong Liu, Caryn Naekyung Kim, Jie Yang, Ronald Jemmerson, and Xiaodong Wang (1996). Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c. Cell, 86, 147-157.