姚雪彪

姚雪彪 长江学者，特聘教授。



八零年至八五年，就读于江西医学院，获学士学位，九一年就学于加大伯克莱分校，于九五年获细胞分子生物学博士学位。其后在加大圣迭哥分校从事博士后研究。于九八年聘为威州助理教授。九九年入选教育部“长江计划”中国科学技术大学生命科学学院特聘教授。



主要研究工作及兴趣：



以胃壁细胞为模式研究系统，从事细胞骨架在上皮细胞分泌中的作用和肌动蛋白异型的功能特异性的研究，并取得重大进展。首次发现了两个肌动蛋白异型（β和γ-Actin）在上皮细胞中的极化分布现象，并首次证实了肌动蛋白异型有不同的生化特性。同时第一次阐述了肌动蛋白的粘连蛋白Ezrin是钙依赖性蛋白水解酶的底物。于九五年赴加州大学圣迭哥分校从事细胞分裂过程中染色体移动的机理研究，其研究首次证实了着丝点粘连蛋白E (CENP-E) 不仅介导染色体移动，而且控制纺锤体调控点信号传递，从而达到细胞分裂期行进的调控。九八年受聘为威州大学助理教授后，继续从事染色体动力学和上皮细胞转运机理等方面的细胞生物学研究。其研究工作获得美国国立卫生总署，美国癌症协会，美国消化健康基金会等机构的奖励和资助。



　



论著：



RECENT PUBLICATIONS



⑴Yao, X., Y. Zheng, K. Sullivan, and D.W. Cleveland. The kinetochore-associated microtubule motor CENP-E is essential for stable attachment of microtubules to mammalian kinetochores and for the mitotic checkpoint. (submitted)



⑵Yao, X., K.F. Sullivan, and D.W. Cleveland. 2000. Deconvolution microscopic image of a mitotic spindle. Cell. 100：1



⑶Forte, J.G., B. Ly, S. Ogihara, M. Ramilo, and X. Yao. 1998. The state of actin in gastric parietal cells. Am. J. Physiol. 274:C97-104 .



⑷Yao,X., K.L. Anderson, and D.W. Cleveland. 1997. The microtubule-dependent motor centromere-associated protein E (CENP-E) an integral component of kinetochore corona fibers that link centromeres to spindle microtubules. J .Cell Biol. 139:435-447.



⑸Urushidant, T., X., Yao, J.G. Forte, and T. Nagao. 1997. ME3407, a new antiulcer agent, inhibits acid secretion via the interfere of intracellular redistribytion of gastric proton pump. Am. J. Physiol. 35:G1122-1134.



⑹Yao, X., X. Peng, D.C. Chow, J.G. Forte, and M. Bennett. 1997. Association of syntaxin 3 and vesicle-associated membrane protein with H,K-ATPase-containing tubulovesicles in gastric parietal cells. Mol. Biol. Cell.8:399-409.



⑺Karam, S., X. Yao, and J.G. Forte. 1997. Functional heterogeneity in parietal cell population along the pit-glands axis. Am. J. Physiol, 35: G161-171.



⑻Yao, X., and J.G. Forte. 1996. Membrane-cytoskeleton interaction underlying regulated secretion in epithelial cells. Curr. Topics in membrane. Edited by W.J. Nelson, 43: 73-96.



⑼Yao, X., S. Karam, M. Ramilo, Q. Rong, and J.G. Forte. 1996. Dissection of intracellular signaling underlying acid secretion using α-toxin-permeabilized gastric gland model. Am. J. Physiol. 270;C61-C73.



⑽Yao, X., L. Cheng, and J.G. Forte. 1996. Characterization of the interaction of gastric ezrin with actin. J. Biol.Chem. 271:7224-7229.



⑾Forte, J.G., and X. Yao.1996. The Membrane-recruitment-and-recycling hypothesis of gastric HCl secretion. Trends Cell Biol. 6:45-48.



⑿Yao, X., C. Chaponnier, G. Gabbiani, and J.G. Forte. 1995. Polarized distribution of actin isoforms in gastric parietal cells. Mole. Biol. Cell. 6:541-557.



⒀Thibodeau, A., R.C. Kuo, J. M. Crothers, X. Yao, J.X. Owicki, and J.G. Forte. 1994. Direct measurement of extracellular proton flux from isolated gastric glands. Am. J. Physiol. 267: C1473-1482.



⒁Yao, X., and J.G. Forte. 1994. Activation of calpain in gastric parietal cells, In Molecular and Cellular Mechanisms of H+ Transport.B.H. Hirst, editor. Springer, Heidelberg. 341-349.



⒂Thibodeau, A., X. Yao, and J.G. Forte. 1994. Acid secretion in α-toxin-permeabilized gastric glands. Biochem. Cell Biol. 72: 26-35.



⒃Yao, X,. A. Thibodeau, and J.G. Forte.1993. Ezrin-calpain I interaction in gastric parietal cells, Am. J. Physiol. 265; C36-46.