postdoc position available

Postdoctoral position is available at Cornell University starting September 2008 to study mechanisms involved in neuro-degeneration and axon regeneration. Motivated individuals with molecular biology and cell biology experiences are encouraged to apply. Experiences with neuronal cultures will be a plus. If interested, please send CV, list of research experiences and contact information of three referees to fenghua.hu@yale.edu.

[此贴子已经被作者于2008-7-7 4:23:25编辑过]

Postdoctoral Opportunities in Neurodegeneration and Stem Cell Research
Two highly motivated individuals with doctoral training in cell biology, biochemistry and other closely realted life sciences are being sought for postdoctoral positions in the Neurodegeneration Research Group at Garvan Institute, Sydney, Australia. Our group uses sophisticated approaches to understand how synaptic dysfunction leads to neurodegeneration and to identify potential approaches to reverse the disease process. Another focus of our group is studying the mechanisms underlying regeneration in the nervous system, and identifying approaches that could drive recovery in the brain in diseases such as Parkinson’s and Alzheimer’s disease.
1. Neural Regeneration Research and Studies of Stem Cells: Adult neurogenesis is the process by which the brain generates new nerve cells in the adult central nervous system (CNS) from stem cells that naturally exist in the braijn. Stimulating neurogenesis may potentially offer a therapeutic approach for neurodegenerative diseases such as Parkinson’s disease, Alzheimer’s disease, and spinal disorders. The postdoctoral fellow will be working to identify mechanisms that regulate adult neurogenesis (neural repair mechanisms) in the normal and diseased brain, to determine if manipulating these mechanisms may offer therapeutic potential. The project involves: (1) stereotaxic survival surgery and gene therapy approaches, (2) immunohistochemistry combined with advanced confocal microscopy and stereology for analysis of regeneration, (3) use of in vitro cell systems, including neural stem cells, for studying neurogenesis, and (4) behavioural testing to determine the capacity for functional recovery in animal models. Preference will be given to individuals with experience in stem cell research and mouse analyses.
2. Neurodegeneration Research and Studies of Synapses: When neurons in the brain that secrete dopamine die, this causes Parkinson’s disease, which leads to a profound loss of motor function and eventually death. The biology of dopamine neurons, which is absolutely critical to a range of diseases such as Parkinson’s disease, is poorly understood. The postdoctoral fellow will be studying dopamine neuron synapses to develop a greater understanding of the role that dopamine synaptic function in normal behavior and in disease. The project invloves: (1) culture of primary cells from mouse neural tissue, including glial cells, dopamine neurons and hippocampal neurons, (2) immunocytochemistry combined with advanced confocal live imaging microscopy, (3) advanced methods in microscopy for analysing active synapses formed by live neurons, and (4) new concepts and techniques that few labs worldwide are able to achieve. Preference will be given to individuals with experience in synapse study.
Candidates must hold a doctoral degree in an appropriate field of biological sciences. Strong English speaking and writing skills are absolute essentials. Remuneration will be based on expertise and experience. The initial appointment will be for one year with the possibility of extension based on performance.
Contact: Dr Bryce Vissel, Neurodegeneration Research Group, Garvan Institute, Sydney, NSW 2010, Australia.
Phone: +61-2-9295 8293; email: b.vissel@garvan.org.au

Postdoctoral Fellow Position
Area: Neuroscience and Cell biology
Starting date: September 1, 2008 or later
Principal Investigator: Bing Ye, Ph.D.

One postdoctoral fellow position is available in my new lab in the Life Sciences Institute of University of Michigan.  My lab works on how different parts of a neuron form in development, change in plasticity, and become defective in diseases in both Drosophila and mammals.  Specifically, we study how dendrites develop differently from axons, and how dendrites become compartmentalized into distinct functional domains. 

We take advantage of a variety of techniques including genetics, cell biology, biochemistry, molecular biology, and cell culture.  One major approach is advanced imaging techniques, including in vivo confocal and two-photon imaging, photoactivation/conversion, and FRAP.

Ph.D.’s in, but not limited to, the broad field of Neuroscience or Cell Biology are encouraged to apply.  Candidates with experience in neuronal cell biology, synapse development and function, or live imaging are strongly encouraged to apply although such skills are not required.  Interested candidates please email CV, brief description of research experience and interest, names and contact information of 3 references to Dr. Bing Ye at bing.ye@ucsf.edu



Selected papers:

Ye B, Zhang Y, Song W, Younger SH, Jan LY, Jan YN.
Growing dendrites and axons differ in their reliance on the secretory pathway.
Cell. 2007 Aug 24;130(4):717-29

Ye B, Jan YN.
The cadherin superfamily and dendrite development.
Trends Cell Biol. 2005 Feb;15(2):64-7.

Ye B, Petritsch C, Clark IE, Gavis ER, Jan LY, Jan YN.
Nanos and Pumilio are essential for dendrite morphogenesis in Drosophila peripheral neurons.
Curr Biol. 2004 Feb 17;14(4):314-21

Ye B, Liao D, Zhang X, Zhang P, Dong H, Huganir RL.
GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.
Neuron. 2000 Jun;26(3):603-17

One postdoctoral fellow position is available in the Department of Cellular Biology & Anatomy, Louisiana State University Health Sciences Center in Shreveport, Louisiana. We are looking for experienced cellular and molecular biologists to join our team and work on stem cell-based and gene therapy for Parkinson’s disease (PD). Experimental skills are required to make animal models of PD, to do behavioral analysis using motor and cognitive tasks for mice and rats, and to process animal brains for immunocytochemistry. Other experimental skills are preferred for stem cell and primary neuronal cell cultures, cloning and production of viral vectors, FACS, Western blot, quantitative real-time PCR, ELISA, confocal microscope. Applicants should have a PhD or an MD. The ideal candidates will be highly motivated, and have good analytical, writing, communication skills. Salary includes benefits will be commensurate with expertise. Individuals who are interested in the position should submit curriculum vitae, summary of research interests, and contact information of three references to Wei-Ming Duan, MD., PhD. at email: wduan@lsuhsc.edu

 

Postdoc position open at Biogen Idec, listed under the careers section at www.biogenidec.com.   Job Title Postdoctoral Scientist Location US-CA-San Diego Job Category Research & Preclinical Development Requisition Number 9215BR Job Description The translational oncobiology group has an immediate opening for a highly motivated postdoctoral scientist to pursue research at the forefront of cancer biology. The position will involve research efforts directed at understanding how specific cancer therapeutics drive apoptotic cell death in leukemia cells and how this can be applied to the treatment of hematological cancers. Qualifications The candidate will have a Ph.D. in the area of cancer biology, a demonstrated record of scientific achievement, and an interest in applying basic cancer biology research to clinical oncology. Expertise in a wide range of molecular and cellular techniques relevant to cancer biology is necessary; prior experience in apoptosis signaling is preferred but not essential. The candidate should possess a demonstrated ability to work independently in the design, execution and interpretation of complex experiments. Excellent written and oral communication skills in addition to a strong desire to excel in a multi-disciplinary team environment are also essential. Education Ph.D. in the biological sciences (0-3 years postgraduate experience)

 

---------------------------------------------------------------------------

The Institute of Medical Biology (IMB) (www.imb.a-star.edu.sg) is the newest research institute of Singapore’s Agency for Science, Technology and Research (A*STAR). Its mission is to understand the mechanisms of human disease and to find new and effective therapeutic strategies for improved quality of life. IMB is developing internationally excellent research programs to work with clinical collaborators at the challenging interface between basic science and medicine. We are located at Biopolis, the international biomedical hub where A*STAR research institutes live alongside biotech companies in a cluster of futuristic laboratory buildings that share excellent scientific core facilities.

 

Distinguished scientists in the fields of Stem Cell and Developmental biology have recently joined the IMB and are seeking post-doctoral fellows for the following projects:

 

(1) Bruno Reversade: Genetic and functional investigations of rare human pedigrees with outstanding phenotypes (e.g. identical twinning) and/or novel syndromes causing hereditary birth defects.

 

(2) Ray Dunn:  Specification of definitive endoderm and early pancreatic progenitors in differentiating human ES cells.

 

(3) Alan Colman: Disease-specific embryonic stem and iPS cells as surrogate models of human disease.

 

(4) Takahiro Nakano: Identification and isolation of a specific neural cell type induced from human ES cells using enhancer-based reporter system.

 

(5) Davor Solter and Barbara Knowles: (i) Molecular control of the oocyte to embryo transition; and (ii) Epigenetic reprogramming of adult cells into ES cells

 

(6) Prabha Sampath: Human Embryonic stem cells: a model system to study translational regulation in development and pathophysiological conditions.

 

 IMB provides a competitive remuneration package commensurate with your specific qualifications and experience. We welcome interested applicants to e-mail a full CV plus names/contact details of three referees, stating preferred area of interest, to Dr. Vandana Ramachandran (mailto:vandana@imb.a-star.edu.sg).